1. Groups of young rats were kept in a hypoxic chamber or in air as control animals for 28 days.
2. Hypoxic and control animals were treated with either α-methyl-3,4-dihydroxyphenylalanine (α-methyldopa) or distilled water.
3. α-Methyldopa significantly reduced the increase in pulmonary artery pressure and right ventricular hypertrophy induced by chronic hypoxia and partially prevented the histological changes in the small pulmonary vessels.
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© 1977 The Biochemical Society and the Medical Research Society
1977
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