1. Rabbits in balance on a low sodium diet were given doses of sodium chloride either orally or intravenously.

2. Those receiving oral doses responded with a much greater natriuresis than those receiving intravenous ones.

3. This could be explained by the existence of a sodium input monitor somewhere in the gut or portal circulation.

Keywords:
hyponatraemia, renal physiology, sodium balance
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© 1975 The Biochemical Society and the Medical Research Society
1975
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