1. Plasma renin concentration (PRC) in newborns greatly exceeded PRC in children and adults. PRC in cord plasma of newborns was higher than peripheral venous PRC in their mothers. PRC in the newborns increased further in the first 48 h post partum and then gradually decreased.

2. The mean PRC of healthy children and adults on free sodium intake decreased with age by an exponential function.

3. The absolute increase of PRC in response to upright posture (PRCupright — PRCrecumbent) decreased with age. The relative increase of PRC in response to upright posture (PRCuprjght:PRCrecumbent) remained unchanged with age, the PRC in upright posture being about twice the basal PRC in all age groups.

Keywords:
age-dependent renin, renin in childhood, plasma renin concentration
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© 1994 The Biochemical Society and the Medical Research Society
1994
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