The authors of the original article “Unpuzzling COVID-19: tissue-related signaling pathways associated with SARS-CoV-2 infection and transmission” (Clin Sci (Lond) (2020) 134(16), DOI: 10.1042/CS20200904) would like to correct Figures 2 and 3 of their article as they have noted that these were inverted at article submission. The figures are presented with their correct order here.
Canonical ACE2 pathway links multiple organ damage in COVID-19
Signaling pathways involved in COVID-19 pathophysiology
The authors apologise for any inconvenience caused to the reader.
References
1. (
Gheblawi
M.
, Wang
K.
, Viveiros
A.
, Nguyen
Q.
, Zhong
J.-C.
, Turner
A.J.
et al.2020
) Angiotensin-converting enzyme 2: SARS-CoV-2 receptor and regulator of the renin-angiotensin system: celebrating the 20th anniversary of the discovery of ACE2
. Circ. Res.
126
, 1456
–1474
[PubMed]
2. (
Perrotta
F.
, Matera
M.G.
, Cazzola
M.
and Bianco
A.
2020
) Severe respiratory SARS-CoV2 infection: Does ACE2 receptor matter?
Respir. Med.
168
, 105996
[PubMed]
3. (
Groß
S.
, Jahn
C.
, Cushman
S.
, Bär
C.
and Thum
T.
2020
) SARS-CoV-2 receptor ACE2-dependent implications on the cardiovascular system: From basic science to clinical implications
. J. Mol. Cell Cardiol.
144
, 47
–53
[PubMed]
4. (
Tian
S.
, Xiong
Y.
, Liu
H.
, Niu
L.
, Guo
J.
, Liao
M.
et al.2020
) Pathological study of the 2019 novel coronavirus disease (COVID-19) through postmortem core biopsies
. Mod. Pathol.
10
–12
5. (
Sabroe
I.
, Parker
L.C.
, Dower
S.K.
and Whyte
M.K.B.
2008
) The role of TLR activation in inflammation
. J. Patho.
214
, 126
–135
6. (
Totura
A.L.
, Whitmore
A.
, Agnihothram
S.
, Schäfer
A.
, Katze
M.G.
, Heise
M.T.
et al.2015
) Toll-like receptor 3 signaling via TRIF contributes to a protective innate immune response to severe acute respiratory syndrome coronavirus infection
. MBio
6
, 1
–14
7. (
Li
Q.
and Verma
I.M.
2002
) NF-κB regulation in the immune system
. Nat. Rev. Immunol.
2
, 725
–734
[PubMed]
8. (
Tergaonkar
V.
, Correa
R.G.
, Ikawa
M.
and Verma
I.M.
2005
) Distinct roles of IκB proteins in regulating constitutive NF-κB activity
. Nat. Cell Biol.
7
, 921
–923
[PubMed]
9. (
Tergaonkar
V.
2006
) NFκB pathway: A good signaling paradigm and therapeutic target
. Int. J. Biochem. Cell Biol.
38
, 1647
–1653
, Available from: https://linkinghub.elsevier.com/retrieve/pii/S1357272506001245
[PubMed]
10.
11. (
Grimes
J.M.
and Grimes
K.V.
2020
) p38 MAPK inhibition: A promising therapeutic approach for COVID-19
. J. Mol. Cell Cardiol.
144
, 63
–65
[PubMed]
12. (
Feng
Y.
, Fang
Z.
, Liu
B.
and Zheng
X.
2019
) P38MAPK plays a pivotal role in the development of acute respiratory distress syndrome
. Clinics
74
, 1
–5
13. (
Zhang
C.
, Wu
Z.
, Li
J.W.
, Zhao
H.
and Wang
G.Q.
2020
) The cytokine release syndrome (CRS) of severe COVID-19 and Interleukin-6 receptor (IL-6R) antagonist Tocilizumab may be the key to reduce the mortality
. Int. J. Antimicrob. Agents
55
, © 2020 The Author(s).
2020
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