The authors of the original article “Modulation of microglial phenotypes improves sepsis-induced hippocampus-dependent cognitive impairments and decreases brain inflammation in an animal model of sepsis” (Clinical Science (2020) 134(7), DOI: 10.1042/CS20191322) have acknowledged an error in Figure 3 of their published paper. Figures 3B and D of the original article have been identified as being the same image. The authors would like to apologise for this error. The corrected Figure 3 is provided below. This change does not modify data interpretation of the original article.
Effect of IL-4 and GdCl3 treatment on microglia activation after sepsis
Sepsis was induced by cecal ligation and perforation (CLP), and immediately following surgery animals were treated with IL-4 or GdCl3. Animals were killed at 24 h, 3 or 10 days after surgery and IBA-1 positive cells were determined in the hippocampus of Sham 24 h (A), 3 (B) and 10 days (C); CLP 24h (D), 3 (E) and 10 days (F); CLP + IL-4 24 h (G), 3 (H) and 10 days (I) and CLP + GdCl3 24 h (J), 3 (K) and 10 days (L) by immunohistochemistry. (M) IBA-1 positive cells quantification. Data were expressed as mean ± SD in pg/ml; n = 6 each group. * indicates significant difference from sham; # indicates significant difference from CLP, P <0.05. Original magnification ×40.
Sepsis was induced by cecal ligation and perforation (CLP), and immediately following surgery animals were treated with IL-4 or GdCl3. Animals were killed at 24 h, 3 or 10 days after surgery and IBA-1 positive cells were determined in the hippocampus of Sham 24 h (A), 3 (B) and 10 days (C); CLP 24h (D), 3 (E) and 10 days (F); CLP + IL-4 24 h (G), 3 (H) and 10 days (I) and CLP + GdCl3 24 h (J), 3 (K) and 10 days (L) by immunohistochemistry. (M) IBA-1 positive cells quantification. Data were expressed as mean ± SD in pg/ml; n = 6 each group. * indicates significant difference from sham; # indicates significant difference from CLP, P <0.05. Original magnification ×40.
