Monocytes circulate in the blood and migrate to inflammatory tissues, but their functions can be either detrimental or beneficial, depending on their phenotypes. In humans, classical monocytes are inflammatory cluster of differentiation (CD)14++CD16−CCR2++ cells originated from the bone marrow or spleen reservoirs and comprise ≥92% of monocytes. Intermediate monocytes (CD14++CD16+CCR2+) are involved in the production of anti-inflammatory cytokines [such as interleukin (IL)-10], reactive oxygen species (ROS), and proinflammatory mediators [such as tumor necrosis factor-α (TNF-α) and IL-1β). Nonclassical monocytes (CD14+CD16++CCR2−) are patrolling cells involved in tissue repair and debris removal from the vasculature. Many studies in both humans and animals have shown the importance of monocyte chemoattractant protein-1 (MCP-1) and its receptor [chemokine receptor of MCP-1 (CCR2)] in pathologies, such as atherosclerosis and myocardial infarction (MI). This review presents the importance of these monocyte subsets in cardiovascular diseases (CVDs), and sheds light on new strategies for the blocking of the MCP-1/CCR2 axis as a therapeutic goal for treating vascular disorders.
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June 2017
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The accompanying caption is: Image demonstrates a 3D reconstruction of the neurovascular unit in a hippocampal artery in the mouse brain. For further details, see article by Nizari et al in this issue, pages 1207-1214. Image kindly provided by Cheryl Hawkes.
Review Article|
May 31 2017
Monocyte subtypes and the CCR2 chemokine receptor in cardiovascular disease
Carolina N. França;
1Santo Amaro University—Health Sciences Post Graduation, São Paulo - SP, Brazil
2Federal University of Sao Paulo, Department of Medicine, Cardiology Division, São Paulo - SP, Brazil
Correspondence: Carolina Nunes França (carolufscar24@gmail.com)
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Maria C.O. Izar;
Maria C.O. Izar
2Federal University of Sao Paulo, Department of Medicine, Cardiology Division, São Paulo - SP, Brazil
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Marinella N.S. Hortêncio;
Marinella N.S. Hortêncio
1Santo Amaro University—Health Sciences Post Graduation, São Paulo - SP, Brazil
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Jônatas B. do Amaral;
Jônatas B. do Amaral
3Federal University of Sao Paulo, Department of Otorhinolaryngology, Head and Neck Surgery, São Paulo - SP, Brazil
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Carlos E.S. Ferreira;
Carlos E.S. Ferreira
4Albert Einstein Israeli Hospital, São Paulo - SP, Brazil
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Izabela D. Tuleta;
Izabela D. Tuleta
5Medizinische Klinik und Poliklinik II—Universitätsklinikum Bonn, Bonn - North Rhine-Westphalia, Germany
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Francisco A.H. Fonseca
Francisco A.H. Fonseca
2Federal University of Sao Paulo, Department of Medicine, Cardiology Division, São Paulo - SP, Brazil
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Publisher: Portland Press Ltd
Received:
January 06 2017
Revision Received:
February 17 2017
Accepted:
February 24 2017
Online ISSN: 1470-8736
Print ISSN: 0143-5221
© 2017 The Author(s). published by Portland Press Limited on behalf of the Biochemical Society
2017
Clin Sci (Lond) (2017) 131 (12): 1215–1224.
Article history
Received:
January 06 2017
Revision Received:
February 17 2017
Accepted:
February 24 2017
Citation
Carolina N. França, Maria C.O. Izar, Marinella N.S. Hortêncio, Jônatas B. do Amaral, Carlos E.S. Ferreira, Izabela D. Tuleta, Francisco A.H. Fonseca; Monocyte subtypes and the CCR2 chemokine receptor in cardiovascular disease. Clin Sci (Lond) 1 June 2017; 131 (12): 1215–1224. doi: https://doi.org/10.1042/CS20170009
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