The incidence of stroke and myocardial infarction increases in aged patients and it is associated with an adverse outcome. Considering the aging population and the increasing incidence of cardiovascular disease, the prediction for population well-being and health economics is daunting. Accordingly, there is an unmet need to focus on fundamental processes underlying vascular aging. A better understanding of the pathways leading to arterial aging may contribute to design mechanism-based therapeutic approaches to prevent or attenuate features of vascular senescence. In the present review, we discuss advances in the pathophysiology of age-related vascular dysfunction including nitric oxide signalling, dysregulation of oxidant/inflammatory genes, epigenetic modifications and mechanisms of vascular calcification as well as insights into vascular repair. Such an overview highlights attractive molecular targets for the prevention of age-driven vascular disease.
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January 2015
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Review Article|
September 05 2014
Molecular pathways of arterial aging
Francesco Paneni;
Francesco Paneni
*Cardiology Unit, Department of Medicine, Karolinska University Hospital, Stockholm, Sweden
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Sarah Costantino;
Sarah Costantino
*Cardiology Unit, Department of Medicine, Karolinska University Hospital, Stockholm, Sweden
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Francesco Cosentino
*Cardiology Unit, Department of Medicine, Karolinska University Hospital, Stockholm, Sweden
Correspondence: Professor Francesco Cosentino (email francesco.cosentino@ki.se).
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Publisher: Portland Press Ltd
Received:
May 13 2014
Revision Received:
June 27 2014
Accepted:
July 22 2014
Online ISSN: 1470-8736
Print ISSN: 0143-5221
© The Authors Journal compilation © 2015 Biochemical Society
2015
Clin Sci (Lond) (2015) 128 (2): 69–79.
Article history
Received:
May 13 2014
Revision Received:
June 27 2014
Accepted:
July 22 2014
Citation
Francesco Paneni, Sarah Costantino, Francesco Cosentino; Molecular pathways of arterial aging. Clin Sci (Lond) 1 January 2015; 128 (2): 69–79. doi: https://doi.org/10.1042/CS20140302
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