Activated regulatory T-cells attenuate myocardial ischaemia/reperfusion injury through a CD39-dependent mechanism

Xia, Ni; Jiao, Jiao; Tang, Ting-Ting; Lv, Bing-Jie; Lu, Yu-Zhi; Wang, Ke-Jing; Zhu, Zheng-Feng; Mao, Xiao-Bo; Nie, Shao-Fang; Wang, Qing; Tu, Xin; Xiao, Hong; Liao, Yu-Hua; Shi, Guo-Ping; Cheng, Xiang

doi:10.1042/CS20140672

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Research Article| February 27 2015

Activated regulatory T-cells attenuate myocardial ischaemia/reperfusion injury through a CD39-dependent mechanism

Ni Xia;

Ni Xia ¹

*Laboratory of Cardiovascular Immunology, Institute of Cardiology, Union Hospital, Tongji Medical College of Huazhong University of Science and Technology; Laboratory of Biological Targeted Therapy of the Ministry of Education, Wuhan 430022, China

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Jiao Jiao;

Jiao Jiao ¹

*Laboratory of Cardiovascular Immunology, Institute of Cardiology, Union Hospital, Tongji Medical College of Huazhong University of Science and Technology; Laboratory of Biological Targeted Therapy of the Ministry of Education, Wuhan 430022, China

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Ting-Ting Tang;

Ting-Ting Tang

*Laboratory of Cardiovascular Immunology, Institute of Cardiology, Union Hospital, Tongji Medical College of Huazhong University of Science and Technology; Laboratory of Biological Targeted Therapy of the Ministry of Education, Wuhan 430022, China

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Bing-Jie Lv;

Bing-Jie Lv

*Laboratory of Cardiovascular Immunology, Institute of Cardiology, Union Hospital, Tongji Medical College of Huazhong University of Science and Technology; Laboratory of Biological Targeted Therapy of the Ministry of Education, Wuhan 430022, China

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Yu-Zhi Lu;

Yu-Zhi Lu

*Laboratory of Cardiovascular Immunology, Institute of Cardiology, Union Hospital, Tongji Medical College of Huazhong University of Science and Technology; Laboratory of Biological Targeted Therapy of the Ministry of Education, Wuhan 430022, China

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Ke-Jing Wang;

Ke-Jing Wang

*Laboratory of Cardiovascular Immunology, Institute of Cardiology, Union Hospital, Tongji Medical College of Huazhong University of Science and Technology; Laboratory of Biological Targeted Therapy of the Ministry of Education, Wuhan 430022, China

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Zheng-Feng Zhu;

Zheng-Feng Zhu

*Laboratory of Cardiovascular Immunology, Institute of Cardiology, Union Hospital, Tongji Medical College of Huazhong University of Science and Technology; Laboratory of Biological Targeted Therapy of the Ministry of Education, Wuhan 430022, China

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Xiao-Bo Mao;

Xiao-Bo Mao

*Laboratory of Cardiovascular Immunology, Institute of Cardiology, Union Hospital, Tongji Medical College of Huazhong University of Science and Technology; Laboratory of Biological Targeted Therapy of the Ministry of Education, Wuhan 430022, China

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Shao-Fang Nie;

Shao-Fang Nie

*Laboratory of Cardiovascular Immunology, Institute of Cardiology, Union Hospital, Tongji Medical College of Huazhong University of Science and Technology; Laboratory of Biological Targeted Therapy of the Ministry of Education, Wuhan 430022, China

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Qing Wang;

Qing Wang

†Center for Cardiovascular Genetics, Department of Molecular Cardiology, Lerner Research Institute, Cleveland Clinic, Cleveland, OH 44195, U.S.A.

‡Key Laboratory of Molecular Biophysics of the Ministry of Education, Cardio-X Institute, College of Life Science and Technology and Center of Human Genome Research, Huazhong University of Science and Technology, Wuhan 430074, China

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Xin Tu;

Xin Tu

‡Key Laboratory of Molecular Biophysics of the Ministry of Education, Cardio-X Institute, College of Life Science and Technology and Center of Human Genome Research, Huazhong University of Science and Technology, Wuhan 430074, China

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Hong Xiao;

Hong Xiao

§Department of Scientific Research, The 4th Hospital of Wuhan, Wuhan 430000, China

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Yu-Hua Liao;

Yu-Hua Liao

*Laboratory of Cardiovascular Immunology, Institute of Cardiology, Union Hospital, Tongji Medical College of Huazhong University of Science and Technology; Laboratory of Biological Targeted Therapy of the Ministry of Education, Wuhan 430022, China

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Guo-Ping Shi;

Guo-Ping Shi

¶Department of Medicine, Brigham and Women's Hospital and Harvard Medical School, Boston, MA 02115, U.S.A.

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Xiang Cheng

*Laboratory of Cardiovascular Immunology, Institute of Cardiology, Union Hospital, Tongji Medical College of Huazhong University of Science and Technology; Laboratory of Biological Targeted Therapy of the Ministry of Education, Wuhan 430022, China

Correspondence: Dr Xiang Cheng (email nathancx@mail.hust.edu.cn).

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Author and article information

Publisher: Portland Press Ltd

Received: October 27 2014

Revision Received: December 15 2014

Accepted: January 05 2015

Accepted Manuscript online: January 05 2015

Online ISSN: 1470-8736

Print ISSN: 0143-5221

2015

Clin Sci (Lond) (2015) 128 (10): 679–693.

https://doi.org/10.1042/CS20140672

Regulatory T lymphocytes (Tregs) are regarded as key immunomodulators in immune-mediated disorders. Our data validated a protective role of Tregs in myocardial ischemia reperfusion injury (MIRI). Moreover, activated Tregs ameliorated MIRI via a CD39-dependent mechanism, representing a putative therapeutic strategy.

2015

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