miRNAs (microRNAs) are novel post-transcriptional regulators of gene expression. Several miRNAs, expressed exclusively in muscle, play important roles during muscle development, growth and regeneration; other ubiquitously expressed miRNAs are also essential for muscle function. In the present review, we outline the miRNAs involved in embryonic muscle development and those that have been found to be dysregulated in diseases associated with skeletal muscle or are changed during muscle adaptation. miRNAs are promising biomarkers and candidates for potential therapeutic intervention. We discuss the strategies that aim to develop novel therapies through modulating miRNA activity. In time, some of these approaches may become available to treat muscle-associated diseases.
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Review Article|
August 01 2012
microRNAs in skeletal muscle differentiation and disease
Katarzyna Goljanek-Whysall;
Katarzyna Goljanek-Whysall
1
*School of Biological Sciences, University of East Anglia, Norwich Research Park, Norwich NR4 7TJ, U.K.
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Dylan Sweetman;
Dylan Sweetman
1
†Division of Animal Sciences, School of Biosciences, University of Nottingham, Sutton Bonington Campus, Loughborough, Leicestershire LE12 5RD, U.K.
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Andrea E. Münsterberg
*School of Biological Sciences, University of East Anglia, Norwich Research Park, Norwich NR4 7TJ, U.K.
Correspondence: Professor Andrea Münsterberg (email a.munsterberg@uea.ac.uk).
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Publisher: Portland Press Ltd
Received:
December 07 2011
Revision Received:
April 05 2012
Accepted:
May 21 2012
Online ISSN: 1470-8736
Print ISSN: 0143-5221
© The Authors Journal compilation © 2012 Biochemical Society
2012
Clin Sci (Lond) (2012) 123 (11): 611–625.
Article history
Received:
December 07 2011
Revision Received:
April 05 2012
Accepted:
May 21 2012
Citation
Katarzyna Goljanek-Whysall, Dylan Sweetman, Andrea E. Münsterberg; microRNAs in skeletal muscle differentiation and disease. Clin Sci (Lond) 1 December 2012; 123 (11): 611–625. doi: https://doi.org/10.1042/CS20110634
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