Recent findings suggests that PDE4D (gene encoding phosphodiesterase 4D) is a stroke-related gene in the Icelandic population, but it is still very controversial as to whether it is a susceptible gene for stroke in other populations. In the present study, we attempted to explore the role of the gene in the pathogenesis of stroke in the Chinese Han population of eastern China. A total of 649 ischaemic stroke patients and 761 unrelated control individuals with no history of stroke or transient ischaemic attack were examined in a case-control study. Four SNPs (single nucleotide polymorphisms) rs152312 (C/T), SNP56 (A/T), SNP83 (C/T) and SNP87 (C/T) with a minor allele frequency over 5% were genotyped and the corresponding haplotypes were constructed. In an analysis of the combined cardiogenic and carotid stroke group, both the allele (P=0.0060) and genotype (P=0.0160) frequencies between cases and controls at SNP83 showed significant differences. However, no difference in haplotype frequencies was observed between cases and controls at rs152312 and SNP56. In the analysis of the small-artery-occlusive stroke group, no difference in allele or genotype frequencies was observed at any marker between cases and controls; the global haplotype frequency in rs152312 and SNP56 had a significant difference between cases and controls (P=0.0162); the frequency of haplotype C-A was higher in cases than in controls (P=0.0122). In conclusion, our present findings show that polymorphisms in the PDE4D gene are associated with an increased risk of ischaemic stroke in the Chinese Han population. The present study adds further support to the role of PDE4D in stroke.
Skip Nav Destination
Article navigation
Research Article|
August 17 2009
Association between the PDE4D gene and ischaemic stroke in the Chinese Han population
Yun Sun;
Yun Sun
1
*Institute for Nutritional Sciences, Shanghai Institutes for Biological Sciences, Chinese Academy of Sciences, Shanghai 200031, China
†Bio-X Center, Shanghai Jiao Tong University, Shanghai 200030, China
Search for other works by this author on:
Yanyan Huang;
Yanyan Huang
1
‡Geriatric Department, Huashan Hospital, Medical Center of Fudan University, Shanghai 200040, China
Search for other works by this author on:
Xu Chen;
Xu Chen
§Department of Neurology, Shanghai No.8 People's Hospital, Shanghai 200233, China
Search for other works by this author on:
Yun Liu;
Yun Liu
*Institute for Nutritional Sciences, Shanghai Institutes for Biological Sciences, Chinese Academy of Sciences, Shanghai 200031, China
†Bio-X Center, Shanghai Jiao Tong University, Shanghai 200030, China
Search for other works by this author on:
Xiaozhe Lu;
Xiaozhe Lu
‡Geriatric Department, Huashan Hospital, Medical Center of Fudan University, Shanghai 200040, China
Search for other works by this author on:
Yongyong Shi;
Yongyong Shi
†Bio-X Center, Shanghai Jiao Tong University, Shanghai 200030, China
Search for other works by this author on:
Wei Tang;
Wei Tang
†Bio-X Center, Shanghai Jiao Tong University, Shanghai 200030, China
Search for other works by this author on:
Jiandong Yang;
Jiandong Yang
*Institute for Nutritional Sciences, Shanghai Institutes for Biological Sciences, Chinese Academy of Sciences, Shanghai 200031, China
†Bio-X Center, Shanghai Jiao Tong University, Shanghai 200030, China
Search for other works by this author on:
Wuyan Chen;
Wuyan Chen
†Bio-X Center, Shanghai Jiao Tong University, Shanghai 200030, China
Search for other works by this author on:
Xinzhi Zhao;
Xinzhi Zhao
†Bio-X Center, Shanghai Jiao Tong University, Shanghai 200030, China
Search for other works by this author on:
Linghan Gao;
Linghan Gao
†Bio-X Center, Shanghai Jiao Tong University, Shanghai 200030, China
Search for other works by this author on:
Sheng Li;
*Institute for Nutritional Sciences, Shanghai Institutes for Biological Sciences, Chinese Academy of Sciences, Shanghai 200031, China
Correspondence: Dr Sheng Li (email sli01@sibs.ac.cn) or Dr Lin He (email helin@bio-x.cn).
Search for other works by this author on:
Guoyin Feng;
Guoyin Feng
∥Shanghai Institute of Mental Health, Shanghai 200030, China
Search for other works by this author on:
Lin He
*Institute for Nutritional Sciences, Shanghai Institutes for Biological Sciences, Chinese Academy of Sciences, Shanghai 200031, China
†Bio-X Center, Shanghai Jiao Tong University, Shanghai 200030, China
¶Institute of Biomedical Sciences, Fudan University, Shanghai 200032, China
Correspondence: Dr Sheng Li (email sli01@sibs.ac.cn) or Dr Lin He (email helin@bio-x.cn).
Search for other works by this author on:
Publisher: Portland Press Ltd
Received:
September 17 2008
Revision Received:
January 23 2009
Accepted:
February 05 2009
Accepted Manuscript online:
February 05 2009
Online ISSN: 1470-8736
Print ISSN: 0143-5221
© The Authors Journal compilation © 2009 Biochemical Society
2009
Clin Sci (Lond) (2009) 117 (7): 265–272.
Article history
Received:
September 17 2008
Revision Received:
January 23 2009
Accepted:
February 05 2009
Accepted Manuscript online:
February 05 2009
Citation
Yun Sun, Yanyan Huang, Xu Chen, Yun Liu, Xiaozhe Lu, Yongyong Shi, Wei Tang, Jiandong Yang, Wuyan Chen, Xinzhi Zhao, Linghan Gao, Sheng Li, Guoyin Feng, Lin He; Association between the PDE4D gene and ischaemic stroke in the Chinese Han population. Clin Sci (Lond) 1 October 2009; 117 (7): 265–272. doi: https://doi.org/10.1042/CS20080471
Download citation file:
Sign in
Don't already have an account? Register
Sign in to your personal account
You could not be signed in. Please check your email address / username and password and try again.
Captcha Validation Error. Please try again.