Understanding the mechanisms that underlie BP (blood pressure) variation in humans and animal models may provide important clues for reducing the burden of uncontrolled hypertension in industrialized societies. High BP is often associated with increased signalling via G-protein-coupled receptors. Three members of the RGS (regulator of G-protein signalling) superfamily RGS2, RGS4 and RGS5 have been implicated in the attenuation of G-protein signalling pathways in vascular and cardiac myocytes, as well as cells of the kidney and autonomic nervous system. In the present review, we discuss the current state of knowledge regarding their differential expression and function in cardiovascular tissues, and the likelihood that one or more of these alleles are candidate hypertension genes. Together, findings from the studies described herein suggest that development of methods to modulate the expression and function of RGS proteins may be a possible strategy for the treatment and prevention of hypertension and cardiovascular disease.
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March 2009
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Review Article|
February 02 2009
RGS proteins: identifying new GAPs in the understanding of blood pressure regulation and cardiovascular function
Steven Gu;
Steven Gu
1Department of Physiology, University of Toronto, Medical Sciences Building, 1 King's College Circle, Toronto, ON, Canada M5S 1A8
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Carlo Cifelli;
Carlo Cifelli
1Department of Physiology, University of Toronto, Medical Sciences Building, 1 King's College Circle, Toronto, ON, Canada M5S 1A8
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Sean Wang;
Sean Wang
1Department of Physiology, University of Toronto, Medical Sciences Building, 1 King's College Circle, Toronto, ON, Canada M5S 1A8
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Scott P. Heximer
1Department of Physiology, University of Toronto, Medical Sciences Building, 1 King's College Circle, Toronto, ON, Canada M5S 1A8
Correspondence: Dr Scott P. Heximer (email scott.heximer@utoronto.ca).
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Publisher: Portland Press Ltd
Received:
July 07 2008
Revision Received:
September 03 2008
Accepted:
September 16 2008
Online ISSN: 1470-8736
Print ISSN: 0143-5221
© The Authors Journal compilation © 2009 Biochemical Society
2009
Clin Sci (Lond) (2009) 116 (5): 391–399.
Article history
Received:
July 07 2008
Revision Received:
September 03 2008
Accepted:
September 16 2008
Citation
Steven Gu, Carlo Cifelli, Sean Wang, Scott P. Heximer; RGS proteins: identifying new GAPs in the understanding of blood pressure regulation and cardiovascular function. Clin Sci (Lond) 1 March 2009; 116 (5): 391–399. doi: https://doi.org/10.1042/CS20080272
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