Individuals suffering from ATH (adult-type hypolactasia), defined by the LCT (gene encoding lactase-phlorizin hydrolase) C/C−13910 genotype (rs4988235), use less milk and dairy products and may have higher plasma HDL (high-density lipoprotein) and lower triacylglycerol (triglyceride) concentrations than their counterparts without ATH. To investigate the effects of ATH status on the early markers of atherosclerosis, we examined its association with CIMT (carotid intima-media thickness), CAC (carotid artery compliance) and brachial artery FMD (flow-mediated dilation) in a young population-based cohort of otherwise healthy individuals. As part of the Cardiovascular Risk in Young Finns Study, we performed CIMT, CAC and FMD analyses, LCT C/T−13910 genotyping and risk factor determination in 2109 young subjects 24–39 years of age (45% males) at the time of the examination. The consumption of both milk and dairy products was lowest and the consumption of alcohol highest in subjects with the C/C−13910 genotype (P<0.001 for all) in comparison with subjects without ATH (TT+CT). In multivariate analysis, no significant association between ATH status and CIMT, CAC or brachial artery FMD was found after adjustment for the use of alcohol, dairy products and all other major risk factors of coronary artery disease. In otherwise similar statistical analysis, the results remained non-significant when females and males were analysed in their own groups. In conclusion, the finding does not support the involvement of ATH in the pathogenesis of early atherosclerosis.
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Research Article|
October 01 2008
Adult-type hypolactasia is not a predisposing factor for the early functional and structural changes of atherosclerosis: the Cardiovascular Risk in Young Finns Study
Terho Lehtimäki;
*Laboratory of Atherosclerosis Genetics, Department of Clinical Chemistry, Tampere University Hospital and the Medical School at the University of Tampere, 33014 Tampere, Finland
Correspondence: Dr Terho Lehtimäki (email terho.lehtimaki@uta.fi).
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Nina Hutri-Kähönen;
Nina Hutri-Kähönen
†Department of Paediatrics, Tampere University Hospital, 33520 Tampere, Finland
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Mika Kähönen;
Mika Kähönen
‡Department of Clinical Physiology, Tampere University Hospital, 33520 Tampere, Finland
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Jukka Hemminki;
Jukka Hemminki
*Laboratory of Atherosclerosis Genetics, Department of Clinical Chemistry, Tampere University Hospital and the Medical School at the University of Tampere, 33014 Tampere, Finland
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Vera Mikkilä;
Vera Mikkilä
§Division of Nutrition, University of Helsinki, 00014 Helsinki, Finland
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Marika Laaksonen;
Marika Laaksonen
§Division of Nutrition, University of Helsinki, 00014 Helsinki, Finland
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Leena Räsänen;
Leena Räsänen
§Division of Nutrition, University of Helsinki, 00014 Helsinki, Finland
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Nina Mononen;
Nina Mononen
*Laboratory of Atherosclerosis Genetics, Department of Clinical Chemistry, Tampere University Hospital and the Medical School at the University of Tampere, 33014 Tampere, Finland
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Markus Juonala;
Markus Juonala
∥Department of Clinical Physiology, University of Turku, 20014 Turku, Finland
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Jukka Marniemi;
Jukka Marniemi
¶Population Research Laboratory, Department of Health and Functional Capacity, National Public Health Institute, 20520 Turku, Finland
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Jorma Viikari;
Jorma Viikari
**Department of Medicine, University of Turku, 20014 Turku, Finland
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Olli Raitakari
Olli Raitakari
∥Department of Clinical Physiology, University of Turku, 20014 Turku, Finland
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Publisher: Portland Press Ltd
Received:
October 12 2007
Revision Received:
December 11 2007
Accepted:
January 14 2008
Accepted Manuscript online:
January 14 2008
Online ISSN: 1470-8736
Print ISSN: 0143-5221
© The Authors Journal compilation © 2008 Biochemical Society
2008
Clin Sci (Lond) (2008) 115 (9): 265–271.
Article history
Received:
October 12 2007
Revision Received:
December 11 2007
Accepted:
January 14 2008
Accepted Manuscript online:
January 14 2008
Citation
Terho Lehtimäki, Nina Hutri-Kähönen, Mika Kähönen, Jukka Hemminki, Vera Mikkilä, Marika Laaksonen, Leena Räsänen, Nina Mononen, Markus Juonala, Jukka Marniemi, Jorma Viikari, Olli Raitakari; Adult-type hypolactasia is not a predisposing factor for the early functional and structural changes of atherosclerosis: the Cardiovascular Risk in Young Finns Study. Clin Sci (Lond) 1 November 2008; 115 (9): 265–271. doi: https://doi.org/10.1042/CS20070360
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