ALI/ARDS (acute lung injury/acute respiratory distress syndrome) is a severe inflammatory lung disease associated with very high mortality. Importantly, no effective therapy has been developed to date for ALI/ARDS. Neutrophils have been implicated in the pathogenesis of ALI/ARDS, and IL-8 (interleukin-8) has been identified as the main chemotactic factor for neutrophils in lung fluids of patients with ALI/ARDS. Significantly, studies from our laboratory have revealed the presence of anti-IL-8 autoantibody:IL-8 immune complexes in lung fluids from patients with ALI/ARDS. Autoantibodies to several cytokines, including IL-8, have been found in human plasma and other tissues. The function of anticytokine autoantibodies is far from clear; however, in some instances, it has been suggested that such autoantibodies may contribute to the pathogenesis of variety of human diseases. In addition, many of these autoantibodies can form immune complexes with target cytokines. Furthermore, immune complexes consisting of anti-IL-8 autoantibodies and IL-8 are very stable due to the high affinity of autoantibodies against IL-8. These complexes are present in various human tissues, including the lung, as they have been detected in lung fluids from patients with ALI/ARDS. In this review, the significance of the latter findings are explored, and the possible involvement of anti-IL-8 autoantibody:IL-8 immune complexes in pathogenesis of ALI/ARDS is discussed.
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March 2008
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Review Article|
February 12 2008
Anti-interleukin-8 autoantibody:interleukin-8 immune complexes in acute lung injury/acute respiratory distress syndrome
Rafal Fudala;
Rafal Fudala
*Department of Biochemistry, University of Texas Health Center, 11937 US Highway 271, Tyler, TX 75708-3154, U.S.A.
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Agnieszka Krupa;
Agnieszka Krupa
*Department of Biochemistry, University of Texas Health Center, 11937 US Highway 271, Tyler, TX 75708-3154, U.S.A.
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Dorota Stankowska;
Dorota Stankowska
*Department of Biochemistry, University of Texas Health Center, 11937 US Highway 271, Tyler, TX 75708-3154, U.S.A.
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Timothy C. Allen;
Timothy C. Allen
†Department of Pathology, University of Texas Health Center, 11937 US Highway 271, Tyler, TX 75708-3154, U.S.A.
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Anna K. Kurdowska
*Department of Biochemistry, University of Texas Health Center, 11937 US Highway 271, Tyler, TX 75708-3154, U.S.A.
Correspondence: Professor Anna K. Kurdowska (email anna.kurdowska@uthct.edu).
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Publisher: Portland Press Ltd
Received:
August 02 2007
Revision Received:
September 13 2007
Accepted:
October 12 2007
Online ISSN: 1470-8736
Print ISSN: 0143-5221
© The Authors Journal compilation © 2008 Biochemical Society
2008
Clin Sci (Lond) (2008) 114 (6): 403–412.
Article history
Received:
August 02 2007
Revision Received:
September 13 2007
Accepted:
October 12 2007
Citation
Rafal Fudala, Agnieszka Krupa, Dorota Stankowska, Timothy C. Allen, Anna K. Kurdowska; Anti-interleukin-8 autoantibody:interleukin-8 immune complexes in acute lung injury/acute respiratory distress syndrome. Clin Sci (Lond) 1 March 2008; 114 (6): 403–412. doi: https://doi.org/10.1042/CS20070272
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