On the basis of a high correlation, non-HDL-C (non-high-density lipoprotein cholesterol) and apoB (apolipoprotein B) have been suggested to be of equivalent value for clinical practice; however, the strength of this relationship has not been examined in detail in patients with dyslipidaemia. The present study examines the variance of non-HDL-C compared with apoB in 1771 consecutive patients evaluated in a lipid clinic. These patients were divided into normolipidaemic subjects (n=407), type I hyperlipoproteinaemia (n=16), type IIa (n=736) and IIb (n=231) hyperlipoproteinaemia, type III hyperlipoproteinaemia (n=38), type IV hyperlipoproteinaemia (n=509) and type V hyperlipoproteinaemia (n=101). The relationship between non-HDL-C and apoB was examined both in terms of correlation and concordance. Correlation was high, but concordance was only moderate in the normolipidaemic subjects and in those with type IIa and type IIb hyperlipoproteinaemia. Correlation and concordance were both low in the subgroups with type III and type V hyperlipoproteinaemia. In those with type IV hyper-lipoproteinaemia, correlation was moderately high (r=0.74), but concordance was only fair. In conclusion, our results indicate that there is substantial variance of apoB for given values of non-HDL-C in many dyslipidaemic subjects. It follows that correlation is not adequate as a sole judge of equivalence of laboratory parameters.
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January 2008
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Research Article|
December 11 2007
Non-HDL cholesterol and apoB in dyslipidaemia
Allan D. Sniderman;
*The Mike Rosenbloom Laboratory for Cardiovascular Research, McGill University Health Centre, Royal Victoria Hospital, Montreal, QC, Canada H3A 1A1
Correspondence: Professor Allan D. Sniderman (email allansniderman@hotmail.com) or Dr Patrick Couture (email patrick.couture@crchul.ulaval.ca).
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Jean-Charles Hogue;
Jean-Charles Hogue
*The Mike Rosenbloom Laboratory for Cardiovascular Research, McGill University Health Centre, Royal Victoria Hospital, Montreal, QC, Canada H3A 1A1
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Jean Bergeron;
Jean Bergeron
†Lipid Research Centre, Laval University Medical Centre, Quebec City, QC, Canada G1V 4G2
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Claude Gagné;
Claude Gagné
†Lipid Research Centre, Laval University Medical Centre, Quebec City, QC, Canada G1V 4G2
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Patrick Couture
†Lipid Research Centre, Laval University Medical Centre, Quebec City, QC, Canada G1V 4G2
Correspondence: Professor Allan D. Sniderman (email allansniderman@hotmail.com) or Dr Patrick Couture (email patrick.couture@crchul.ulaval.ca).
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Publisher: Portland Press Ltd
Received:
July 30 2007
Revision Received:
September 12 2007
Accepted:
September 17 2007
Accepted Manuscript online:
September 17 2007
Online ISSN: 1470-8736
Print ISSN: 0143-5221
© The Authors Journal compilation © 2008 Biochemical Society
2008
Clin Sci (Lond) (2008) 114 (2): 149–155.
Article history
Received:
July 30 2007
Revision Received:
September 12 2007
Accepted:
September 17 2007
Accepted Manuscript online:
September 17 2007
Citation
Allan D. Sniderman, Jean-Charles Hogue, Jean Bergeron, Claude Gagné, Patrick Couture; Non-HDL cholesterol and apoB in dyslipidaemia. Clin Sci (Lond) 1 January 2008; 114 (2): 149–155. doi: https://doi.org/10.1042/CS20070265
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