The re-establishment of adequate blood flow in a vessel with a reduced lumen due to an atherosclerotic plaque by percutaneous vascular intervention is a well established procedure. However, the long-term outcome of such interventions is negatively influenced by the development of intimal hyperplasia/restenosis. Although extensively researched, this still represents a significant clinical problem. Retinoids, i.e. natural and synthetic derivates of vitamin A, represent a potential therapeutic compound, since they have been shown to influence the vast majority of processes that ultimately lead to reocclusion of the injured vessel. Retinoids exert their effects at the transcriptional level through their nuclear receptors. Targeting multiple processes, i.e. proliferation, migration, extracellular matrix composition and cell differentiation, as well as coagulation/fibrinolysis, should increase their future role in the prevention of restenosis. The purpose of this review is to summarize the diverse effects of retinoids on pathobiological and biological processes activated at sites of vascular injury with particular emphasis on intimal hyperplasia/restenosis after endovascular interventions.
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January 2008
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Review Article|
November 30 2007
Vitamin A: a drug for prevention of restenosis/reocclusion after percutaneous coronary intervention?
Andreas C. Gidlöf;
Andreas C. Gidlöf
*Center for Molecular Medicine, Cardiovascular Research Unit, Karolinska Institute, SE-171 76 Stockholm, Sweden
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Pauline Ocaya;
Pauline Ocaya
†Division of Biomedicine, Department of Clinical Medicine, University of Örebro, SE-701 82 Örebro, Sweden
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Olesya Krivospitskaya;
Olesya Krivospitskaya
†Division of Biomedicine, Department of Clinical Medicine, University of Örebro, SE-701 82 Örebro, Sweden
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Allan Sirsjö
†Division of Biomedicine, Department of Clinical Medicine, University of Örebro, SE-701 82 Örebro, Sweden
Correspondence: Dr Allan Sirsjö (email allan.sirsjo@ikm.oru.se).
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Publisher: Portland Press Ltd
Received:
March 19 2007
Revision Received:
May 17 2007
Accepted:
May 23 2007
Online ISSN: 1470-8736
Print ISSN: 0143-5221
© The Authors Journal compilation © 2008 Biochemical Society
2008
Clin Sci (Lond) (2008) 114 (1): 19–25.
Article history
Received:
March 19 2007
Revision Received:
May 17 2007
Accepted:
May 23 2007
Citation
Andreas C. Gidlöf, Pauline Ocaya, Olesya Krivospitskaya, Allan Sirsjö; Vitamin A: a drug for prevention of restenosis/reocclusion after percutaneous coronary intervention?. Clin Sci (Lond) 1 January 2008; 114 (1): 19–25. doi: https://doi.org/10.1042/CS20070090
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