In the present study we investigated the association of the RANTES (regulated upon activation, normal T-cell expressed and secreted) −28C>G and −403G>A promoter polymorphisms with the concentration of serum RANTES and CAD (coronary artery disease) in Korean men. We included 553 male CAD patients with (n=176) or without (n=377) Type 2 diabetes, aged 40–65 years with previous myocardial infarction (∼50%) or angiographically confirmed CAD (∼50%), and 416 aged-matched healthy male controls. The main outcome measures were the OR (odds ratio) of CAD risk and the serum RANTES concentration evaluated by sandwich ELISA. Although the RANTES −28C>G genotype had no significant association with CAD risk, the presence of the minor allele of the RANTES −403G>A single nucleotide polymorphism was associated with a lower risk of CAD {OR 0.70 [95% CI (confidence interval) 0.54–0.92], P=0.011} after adjusting for age, BMI (body mass index), cigarette smoking and alcohol consumption. Serum RANTES concentrations were significantly associated with the −403G>A genotype in controls (G/G: 44.7±3.3 ng/ml, G/A: 36.5±2.0 ng/ml, A/A: 28.7±2.5 ng/ml; P<0.001), non-diabetic CAD patients (G/G: 50.9±3.0 ng/ml, G/A: 42.2±2.6 ng/ml, A/A: 41.3±4.4 ng/ml; P<0.05) and diabetic CAD patients (G/G: 58.5±3.5 ng/ml, G/A: 49.6±4.1 ng/ml, A/A: 42.2±4.3 ng/ml; P<0.05); however, such associations were not observed in the subgroup of CAD patients taking lipid-lowering medication. Moreover, serum RANTES was positively correlated with C-reactive protein (r=0.289, P<0.001) and platelet counts (r=0.253, P<0.001). The results of the present study demonstrate that the RANTES −403A allele is associated with lower serum RANTES concentrations and consequently with reduced CAD risk.
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October 2007
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Research Article|
September 12 2007
The RANTES −403G>A promoter polymorphism in Korean men: association with serum RANTES concentration and coronary artery disease
Yangsoo Jang;
Yangsoo Jang
1
*Cardiovascular Genome Center, Cardiovascular Hospital, Severance Hospital, 134 Sinchon-dong, Seodaemun-gu, Seoul 120-752, South Korea
†Cardiology Division, Yonsei University College of Medicine, Yonsei Cardiovascular Center, Cardiovascular Hospital, Severance Hospital, 134 Sinchon-dong, Seodaemun-gu, Seoul 120-752, South Korea
‡Yonsei University Research Institute of Science for Aging, Yonsei University, 134 Sinchon-dong, Seodaemun-gu, Seoul 120-752, South Korea
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Jey Sook Chae;
Jey Sook Chae
1
‡Yonsei University Research Institute of Science for Aging, Yonsei University, 134 Sinchon-dong, Seodaemun-gu, Seoul 120-752, South Korea
§National Research Laboratory of Clinical Nutrigenetics/Nutrigenomics, Yonsei University, Department of Food and Nutrition, College of Human Ecology, Yonsei University, 134 Sinchon-dong, Seodaemun-gu, Seoul 120-752, South Korea
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Yae Jung Hyun;
Yae Jung Hyun
‡Yonsei University Research Institute of Science for Aging, Yonsei University, 134 Sinchon-dong, Seodaemun-gu, Seoul 120-752, South Korea
§National Research Laboratory of Clinical Nutrigenetics/Nutrigenomics, Yonsei University, Department of Food and Nutrition, College of Human Ecology, Yonsei University, 134 Sinchon-dong, Seodaemun-gu, Seoul 120-752, South Korea
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Soo Jeong Koh;
Soo Jeong Koh
‡Yonsei University Research Institute of Science for Aging, Yonsei University, 134 Sinchon-dong, Seodaemun-gu, Seoul 120-752, South Korea
§National Research Laboratory of Clinical Nutrigenetics/Nutrigenomics, Yonsei University, Department of Food and Nutrition, College of Human Ecology, Yonsei University, 134 Sinchon-dong, Seodaemun-gu, Seoul 120-752, South Korea
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Ji Young Kim;
Ji Young Kim
‡Yonsei University Research Institute of Science for Aging, Yonsei University, 134 Sinchon-dong, Seodaemun-gu, Seoul 120-752, South Korea
§National Research Laboratory of Clinical Nutrigenetics/Nutrigenomics, Yonsei University, Department of Food and Nutrition, College of Human Ecology, Yonsei University, 134 Sinchon-dong, Seodaemun-gu, Seoul 120-752, South Korea
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Min Ji Ko;
Min Ji Ko
§National Research Laboratory of Clinical Nutrigenetics/Nutrigenomics, Yonsei University, Department of Food and Nutrition, College of Human Ecology, Yonsei University, 134 Sinchon-dong, Seodaemun-gu, Seoul 120-752, South Korea
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Se-Joong Rim;
Se-Joong Rim
†Cardiology Division, Yonsei University College of Medicine, Yonsei Cardiovascular Center, Cardiovascular Hospital, Severance Hospital, 134 Sinchon-dong, Seodaemun-gu, Seoul 120-752, South Korea
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Hyun-Joon Shin;
Hyun-Joon Shin
†Cardiology Division, Yonsei University College of Medicine, Yonsei Cardiovascular Center, Cardiovascular Hospital, Severance Hospital, 134 Sinchon-dong, Seodaemun-gu, Seoul 120-752, South Korea
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Jose M. Ordovas;
Jose M. Ordovas
∥JM-USDA-HNRCA, Tufts University, Boston, MA 02111, U.S.A.
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Jong Ho Lee
‡Yonsei University Research Institute of Science for Aging, Yonsei University, 134 Sinchon-dong, Seodaemun-gu, Seoul 120-752, South Korea
§National Research Laboratory of Clinical Nutrigenetics/Nutrigenomics, Yonsei University, Department of Food and Nutrition, College of Human Ecology, Yonsei University, 134 Sinchon-dong, Seodaemun-gu, Seoul 120-752, South Korea
Correspondence: Dr Jong Ho Lee (email jhleeb@yonsei.ac.kr).
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Publisher: Portland Press Ltd
Received:
January 08 2007
Revision Received:
May 02 2007
Accepted:
May 15 2007
Accepted Manuscript online:
May 15 2007
Online ISSN: 1470-8736
Print ISSN: 0143-5221
© The Authors Journal compilation © 2007 Biochemical Society
2007
Clin Sci (Lond) (2007) 113 (8): 349–356.
Article history
Received:
January 08 2007
Revision Received:
May 02 2007
Accepted:
May 15 2007
Accepted Manuscript online:
May 15 2007
Citation
Yangsoo Jang, Jey Sook Chae, Yae Jung Hyun, Soo Jeong Koh, Ji Young Kim, Min Ji Ko, Se-Joong Rim, Hyun-Joon Shin, Jose M. Ordovas, Jong Ho Lee; The RANTES −403G>A promoter polymorphism in Korean men: association with serum RANTES concentration and coronary artery disease. Clin Sci (Lond) 1 October 2007; 113 (8): 349–356. doi: https://doi.org/10.1042/CS20070014
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