We read with interest the article by Seko and colleagues [1], who document that serum levels of endostatin and VEGF (vascular endothelial growth factor) are increased markedly in patients with acute myocardial infarction, but subsequently decrease significantly by early reperfusion. We would like to point out important limitations in their findings not addressed in the study. This relates entirely to the administration of intravenous heparin during the reperfusion process. Firstly, we disagree that the significant decrease seen in serum VEGF levels 3–6 h after reperfusion relates to a down-regulation of VEGF production, but, in fact, is entirely due to intravenous heparin administration, which is known to modulate the interaction of VEGF with its receptor [2]. Kawamoto et al. [3] found that the serum concentration of VEGF in patients with acute myocardial infarction was reduced by up to 93% 1 h after administration of intravenous...
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October 2004
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Correspondence|
September 24 2004
Effect of intravenous heparin on serum levels of endostatin, VEGF and HGF
Lokpal BHATIA;
1Cardiac Department, Mid Essex Hospitals NHS Trust, Broomfield Hospital, Court Road, Broomfield, Chelmsford, Essex CM1 7ET, U.K.
Correspondence: Dr Lokpal Bhatia (email lokebhatia@aol.com).
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Gerald J. CLESHAM;
Gerald J. CLESHAM
1Cardiac Department, Mid Essex Hospitals NHS Trust, Broomfield Hospital, Court Road, Broomfield, Chelmsford, Essex CM1 7ET, U.K.
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Delphine R. TURNER
Delphine R. TURNER
1Cardiac Department, Mid Essex Hospitals NHS Trust, Broomfield Hospital, Court Road, Broomfield, Chelmsford, Essex CM1 7ET, U.K.
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Publisher: Portland Press Ltd
Received:
June 04 2004
Accepted:
July 02 2004
Accepted Manuscript online:
July 02 2004
Online ISSN: 1470-8736
Print ISSN: 0143-5221
The Biochemical Society
2004
Clin Sci (Lond) (2004) 107 (4): 423.
Article history
Received:
June 04 2004
Accepted:
July 02 2004
Accepted Manuscript online:
July 02 2004
Citation
Lokpal BHATIA, Gerald J. CLESHAM, Delphine R. TURNER; Effect of intravenous heparin on serum levels of endostatin, VEGF and HGF. Clin Sci (Lond) 1 October 2004; 107 (4): 423. doi: https://doi.org/10.1042/CS20040160
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