Plasma concentrations of HDL (high-density lipoprotein) cholesterol are low in the Saudi Arabian population. A B polymorphism at the CETP (cholesteryl ester protein transfer) locus that is detectable with the restriction enzyme TaqI is a genetic determinant of the plasma HDL cholesterol concentration. We assessed the relationship between the TaqI B CETP polymorphism and lipid and apolipoprotein concentrations in a study sample of 335 Saudi residents. The TaqI B1 and B2 allele frequencies were 0.54 and 0.46 respectively, similar to those in other populations. HDL cholesterol levels in B2B2 homozygotes were significantly higher than in B1B1 homozygotes [1.01 (0.3) compared with 0.92 (0.2) mmol/l; mean (S.D.); P=0.03]. There was also a significant difference between the B2B2 and B1B1 homozygotes with regard to apolipoprotein AI concentration [123.6 (16.4) compared with 113.7 (13.9) mg/dl; P=0.04]. This genetic variation was independent of metabolic risk factors known to influence HDL cholesterol levels. The allele frequency of the TaqI B CETP polymorphism and its relatively modest impact on HDL cholesterol concentrations argue against an important role for this allele, or for strongly linked loci, in determining the low levels of HDL cholesterol seen in the Saudi population.
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Research Article|
October 01 2003
Association between the cholesteryl ester transfer protein TaqI-detectable B polymorphism and low high-density lipoprotein cholesterol concentration in Saudis
Nassr M. AL-DAGHRI;
*Department of Clinical Biochemistry, Birmingham Heartlands Hospital, Birmingham B9 5SS, U.K.
Correspondence: Mr Nasser Al-Daghri (e-mail aldaghri2000@hotmail.com).
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Omer AL-ATTAS;
Omer AL-ATTAS
†College of Science, King Saud University, Riyadh, Saudi Arabia
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Ashok PATEL;
Ashok PATEL
‡Department of Medicine, University of Birmingham, Birmingham B15 2TT, U.K.
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Nikolai D. BELYAEV;
Nikolai D. BELYAEV
‡Department of Medicine, University of Birmingham, Birmingham B15 2TT, U.K.
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William A. BARTLETT;
William A. BARTLETT
*Department of Clinical Biochemistry, Birmingham Heartlands Hospital, Birmingham B9 5SS, U.K.
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Alan F. JONES;
Alan F. JONES
*Department of Clinical Biochemistry, Birmingham Heartlands Hospital, Birmingham B9 5SS, U.K.
§Department of Medicine, Birmingham Heartlands Hospital, Birmingham B9 5SS, U.K.
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Sudesh KUMAR;
Sudesh KUMAR
§Department of Medicine, Birmingham Heartlands Hospital, Birmingham B9 5SS, U.K.
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Steve C. BAIN
Steve C. BAIN
§Department of Medicine, Birmingham Heartlands Hospital, Birmingham B9 5SS, U.K.
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Publisher: Portland Press Ltd
Received:
January 03 2003
Revision Received:
May 27 2003
Accepted:
May 29 2003
Accepted Manuscript online:
May 29 2003
Online ISSN: 1470-8736
Print ISSN: 0143-5221
© 2003 The Biochemical Society
2003
Clin Sci (Lond) (2003) 105 (4): 467–472.
Article history
Received:
January 03 2003
Revision Received:
May 27 2003
Accepted:
May 29 2003
Accepted Manuscript online:
May 29 2003
Citation
Nassr M. AL-DAGHRI, Omer AL-ATTAS, Ashok PATEL, Nikolai D. BELYAEV, William A. BARTLETT, Alan F. JONES, Sudesh KUMAR, Steve C. BAIN; Association between the cholesteryl ester transfer protein TaqI-detectable B polymorphism and low high-density lipoprotein cholesterol concentration in Saudis. Clin Sci (Lond) 1 October 2003; 105 (4): 467–472. doi: https://doi.org/10.1042/CS20030007
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