The relationship between levels of circulating intercellular cell-adhesion molecule-1 (cICAM-1) or P-selectin (cP-selectin) and the severity of carotid atherosclerosis was examined in 301 outpatients undergoing duplex ultrasonographic examination. Carotid plaque was defined as an intima-media thickness greater than 1.0 mm, and a plaque score (PS) was calculated from the plaque thickness in both carotid arteries. Multivariate analysis demonstrated significant positive associations between cICAM-1 and the number of plaques [β = 0.11; confidence interval (CI), 0.007–0.213], maximum intima-media thickness (β = 0.11; CI, 0.01–0.219), and PS (β = 0.10; CI, 0.001–0.205). In contrast, no significant association was found for cP-selectin. cP-selectin did not increase until atherosclerosis was advanced (PS > 10), showing a marked increase in patients with ≥ 50% stenosis. The circulating levels of both proteins are related to real measurements of plaque formation in the carotid arteries independently of classical risk factors. Marked elevation of cP-selectin occurs in advanced carotid atherosclerosis after gradual elevation of cICAM-1.
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Research Article|
May 01 2003
Circulating adhesion molecules are correlated with ultrasonic assessment of carotid plaques
Hiroyuki HASHIMOTO;
1Department of Internal Medicine and Therapeutics, Osaka University Graduate School of Medicine, 2-2 Yamadaoka, Suita, Osaka 565-0871, Japan
Correspondence: Dr Hiroyuki Hashimoto, Department of Internal Medicine, Osaka National Hospital 2-1-14, Hoenzaka, Chuoku, Osaka 540-0006, Japan (e-mail hashih@onh.go.jp).
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Kazuo KITAGAWA;
Kazuo KITAGAWA
1Department of Internal Medicine and Therapeutics, Osaka University Graduate School of Medicine, 2-2 Yamadaoka, Suita, Osaka 565-0871, Japan
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Keisuke KUWABARA;
Keisuke KUWABARA
1Department of Internal Medicine and Therapeutics, Osaka University Graduate School of Medicine, 2-2 Yamadaoka, Suita, Osaka 565-0871, Japan
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Hidetaka HOUGAKU;
Hidetaka HOUGAKU
1Department of Internal Medicine and Therapeutics, Osaka University Graduate School of Medicine, 2-2 Yamadaoka, Suita, Osaka 565-0871, Japan
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Toshiho OHTSUKI;
Toshiho OHTSUKI
1Department of Internal Medicine and Therapeutics, Osaka University Graduate School of Medicine, 2-2 Yamadaoka, Suita, Osaka 565-0871, Japan
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Masayasu MATSUMOTO;
Masayasu MATSUMOTO
1Department of Internal Medicine and Therapeutics, Osaka University Graduate School of Medicine, 2-2 Yamadaoka, Suita, Osaka 565-0871, Japan
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Masatsugu HORI
Masatsugu HORI
1Department of Internal Medicine and Therapeutics, Osaka University Graduate School of Medicine, 2-2 Yamadaoka, Suita, Osaka 565-0871, Japan
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Publisher: Portland Press Ltd
Received:
October 15 2002
Revision Received:
December 16 2002
Accepted:
February 06 2003
Accepted Manuscript online:
February 06 2003
Online ISSN: 1470-8736
Print ISSN: 0143-5221
The Biochemical Society, London ©2003
2003
Clin Sci (Lond) (2003) 104 (5): 521–527.
Article history
Received:
October 15 2002
Revision Received:
December 16 2002
Accepted:
February 06 2003
Accepted Manuscript online:
February 06 2003
Citation
Hiroyuki HASHIMOTO, Kazuo KITAGAWA, Keisuke KUWABARA, Hidetaka HOUGAKU, Toshiho OHTSUKI, Masayasu MATSUMOTO, Masatsugu HORI; Circulating adhesion molecules are correlated with ultrasonic assessment of carotid plaques. Clin Sci (Lond) 1 May 2003; 104 (5): 521–527. doi: https://doi.org/10.1042/CS20020290
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