During uncomplicated pregnancy, the development of proteinuria is accepted as a poor prognostic sign and is associated with increasing maternal and perinatal mortality and morbidity. Physiological proteinuria increases with increasing gestation and one of its largest constituents is albumin. The reference range for the (micro)albumin/creatinine ratio (ACR) has not been described for normal pregnancy. This prospective cross-sectional study describes the gestation-specific 95% reference ranges for urinary microalbumin concentration, creatinine concentration and ACR in uncomplicated pregnancy. There is a significant increase (P = 0.016) in the ACR in the third trimester. The mean difference is 0.091mg of albumin/mmol of creatinine (95% confidence interval, 0.014–0.168). Our results describe the first well-defined gestation-specific 95% reference range for a point-of-care measurement of the ACR. These data are essential if such testing is to be employed in antenatal care.
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Research Article|
January 09 2003
Urinary microalbumin/creatinine ratios: reference range in uncomplicated pregnancy
Jason WAUGH;
*Department of Obstetrics and Gynaecology, University of Leicester, Robert Kilpatrick Building, Leicester Royal Infirmary, Leicester LE2 7LX, U.K.
Correspondence: Mr Jason Waugh (e-mail jason.waugh@uhl-tr.nhs.uk).
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Stephen C. BELL;
Stephen C. BELL
*Department of Obstetrics and Gynaecology, University of Leicester, Robert Kilpatrick Building, Leicester Royal Infirmary, Leicester LE2 7LX, U.K.
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Mark D. KILBY;
Mark D. KILBY
†Department of Maternal/Fetal Medicine, Division of Reproduction and Child Health, Birmingham Womens' Hospital, University of Birmingham, Birmingham B15 2TG, U.K.
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Paul C. LAMBERT;
Paul C. LAMBERT
‡Department of Epidemiology and Public Health, University of Leicester, Leicester LE2 6TP, U.K.
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Claire N. BLACKWELL;
Claire N. BLACKWELL
*Department of Obstetrics and Gynaecology, University of Leicester, Robert Kilpatrick Building, Leicester Royal Infirmary, Leicester LE2 7LX, U.K.
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Andrew SHENNAN;
Andrew SHENNAN
§Maternal and Fetal Research Unit, St Thomas' Hospital, GKT Kings College, London SE1 7EH, U.K.
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Aidan HALLIGAN
Aidan HALLIGAN
*Department of Obstetrics and Gynaecology, University of Leicester, Robert Kilpatrick Building, Leicester Royal Infirmary, Leicester LE2 7LX, U.K.
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Publisher: Portland Press Ltd
Received:
June 26 2002
Revision Received:
September 25 2002
Accepted:
November 19 2002
Online ISSN: 1470-8736
Print ISSN: 0143-5221
The Biochemical Society and the Medical Research Society © 2003
2003
Clin Sci (Lond) (2003) 104 (2): 103–107.
Article history
Received:
June 26 2002
Revision Received:
September 25 2002
Accepted:
November 19 2002
Citation
Jason WAUGH, Stephen C. BELL, Mark D. KILBY, Paul C. LAMBERT, Claire N. BLACKWELL, Andrew SHENNAN, Aidan HALLIGAN; Urinary microalbumin/creatinine ratios: reference range in uncomplicated pregnancy. Clin Sci (Lond) 1 February 2003; 104 (2): 103–107. doi: https://doi.org/10.1042/cs1040103
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