Diabetes is the most common endocrine disorder worldwide, with complications that include the development of both macro- and micro-vascular disease that contribute significantly to patient morbidity and mortality. The severity of diabetic complications is amplified during pregnancy, resulting in a higher incidence of adverse pregnancy outcomes such as pre-eclampsia, placental insufficiency and stillbirth than in non-diabetics. Vascular dysfunction is thought to underlie many of these complications, with the greatest impact occurring at the level of the resistance vasculature, where alterations in vascular reactivity can significantly affect blood flow and tissue perfusion. It is likely that problems associated with diabetic pregnancies are related, in part, to abnormal vascular function, particularly dysfunction of the vascular endothelium.
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Review Article|
November 21 2001
Diabetes and the maternal resistance vasculature
Christine ANG;
Christine ANG
1Department of Obstetrics and Gynaecology, The Queen Mother's Hospital, University of Glasgow, Glasgow G3 8SJ, U.K.
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Mary Ann LUMSDEN
1Department of Obstetrics and Gynaecology, The Queen Mother's Hospital, University of Glasgow, Glasgow G3 8SJ, U.K.
Correspondence: Dr M. A. Lumsden (e-mail M.A.Lumsden@clinmed.gla.ac.uk).
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Publisher: Portland Press Ltd
Online ISSN: 1470-8736
Print ISSN: 0143-5221
The Biochemical Society and the Medical Research Society © 2001
2001
Clin Sci (Lond) (2001) 101 (6): 719–729.
Citation
Christine ANG, Mary Ann LUMSDEN; Diabetes and the maternal resistance vasculature. Clin Sci (Lond) 1 December 2001; 101 (6): 719–729. doi: https://doi.org/10.1042/cs1010719
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