Human adrenomedullin (ADM), a peptide comprising 52 amino acids, is a circulating hormone with vasodilator properties. We have evaluated its release by the heart following ischaemic myocardial damage, as indicated by elevated levels of the cardiospecific protein troponin-T (Tn-T) during cardiopulmonary bypass. ADM (pg/ml) and Tn-T (ng/ml) were measured in coronary sinus blood before and after aortic cross-clamp and in venous blood 6 ;h after surgery in 22 coronary-bypass patients. Based on the pre- and post-clamp Tn-T levels in the coronary sinus, the patients were divided into group I (no change; n = 10) and group II (two times increase; n = 12). Baseline ADM (362.7±106.2 and 303±58.7 pg/ml in groups I and II respectively; means±S.D.) and Tn-T (0.66±0.14 and 0.57±0.13 ng/ml respectively) levels were similar in both groups. In group I, the post-clamp ADM (317.6±80.8 pg/ml) and Tn-T (0.68±0.15 ng/ml) levels did not change significantly. In group II, the post-clamp ADM levels rose significantly above the baseline, mimicking the change in Tn-T (ADM, 541.4±89.4 pg/ml; Tn-T, 1.37±0.31 ng/ml; P = 0.009). After 6 h, the systemic Tn-T levels were similar in both groups (2.09±0.44 and 1.95±0.52 ng/ml in groups I and II respectively). We suggest that: (1) minor degrees of myocardial ischaemic damage result in release of ADM by the heart, and (2) ADM may play a protective role in the myocardium during an ischaemic insult. This suggests a possible therapeutic role for ADM in the management of intra-operative myocardial ischaemia.
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Research Article|
April 01 1999
Coronary sinus adrenomedullin rises in response to myocardial injury
Palaniswamy VIJAY;
*Department of Surgery, Section of Cardiothoracic Surgery, Indiana University School of Medicine, 545 Barnhill Drive, EH 215, Indianapolis, IN 46202, U.S.A., and
Correspondence: Dr. Palaniswamy Vijay.
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Laszlo SZEKELY;
Laszlo SZEKELY
*Department of Surgery, Section of Cardiothoracic Surgery, Indiana University School of Medicine, 545 Barnhill Drive, EH 215, Indianapolis, IN 46202, U.S.A., and
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Thomas X. AUFIERO;
Thomas X. AUFIERO
*Department of Surgery, Section of Cardiothoracic Surgery, Indiana University School of Medicine, 545 Barnhill Drive, EH 215, Indianapolis, IN 46202, U.S.A., and
†RL Roudebush Veterans Affairs Medical Center, 1001 West 10th Street, Indianapolis, IN 46202, U.S.A.
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Thomas G. SHARP
Thomas G. SHARP
*Department of Surgery, Section of Cardiothoracic Surgery, Indiana University School of Medicine, 545 Barnhill Drive, EH 215, Indianapolis, IN 46202, U.S.A., and
†RL Roudebush Veterans Affairs Medical Center, 1001 West 10th Street, Indianapolis, IN 46202, U.S.A.
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Publisher: Portland Press Ltd
Online ISSN: 1470-8736
Print ISSN: 0143-5221
The Biochemical Society and the Medical Research Society © 1999
1999
Clin Sci (Lond) (1999) 96 (4): 415–420.
Citation
Palaniswamy VIJAY, Laszlo SZEKELY, Thomas X. AUFIERO, Thomas G. SHARP; Coronary sinus adrenomedullin rises in response to myocardial injury. Clin Sci (Lond) 1 April 1999; 96 (4): 415–420. doi: https://doi.org/10.1042/cs0960415
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