1. The accelerated model of nephrotoxic serum nephritis (NTSN) was produced in 12 Sprague-Dawley rats. Six of these rats were administered superoxide dismutase (EC 1.15.1.1; SOD) subcutaneously (8 mg/kg) 8-hourly for 4 days. The first dose was given 6 h before the nephrotoxic serum (NTS).

2. The progression of renal disease was monitored by following (i) albumin excretion, (ii) serum creatinine and creatinine clearance and (iii) renal histopathology and immunofluorescence.

3. There was no evidence that SOD influences the course of NTSN.

4. SOD was scarcely excreted by control rats or rats with NTSN.

Keywords:
nephrotoxic nephritis, rat, superoxide, superoxide dismutase
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© 1985 The Biochemical Society and the Medical Research Society
1985
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