1. The effect of arginine vasopressin (AVP) on ureagenesis was measured in isolated rat hepatocytes with ammonium chloride and l(+)-lactate as substrates.

2. AVP was found to stimulate urea synthesis and the dose-response curve suggests that such an effect is present at concentrations of the hormone as low as 25-50 pmol/l.

3. Both the dose-response curve and the concentrations of NH4+ employed suggest that the effect observed could be of physiological significance.

Keywords:
isolated hepatocytes, ureagenesis, urinary concentrating mechanism, vasopressin
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© 1985 The Biochemical Society and the Medical Research Society
1985
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