1. Aldosterone given acutely to male Wistar rats stimulated ouabain-sensitive and ouabain-insensitive 22Na efflux from tail arteries.

2. These effects of aldosterone seem to depend on the activation of specific mineralocorticoid receptors, as they are blocked by antimineralo-corticoid drugs.

3. The results suggest that aldosterone may have a physiological role in the control of vascular tone.

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