1. In response to graded infusions of isoprenaline, adult spontaneously hypertensive rats (20-24 weeks old) showed diminished responses of left ventricular contractile indices, diminished chronotropic responses and impairment of left ventricular relaxation rate as compared with matched Kyoto-Wistar rats.

2. These findings suggest reduced capacity to increase contractility in response to stress.

Keywords:
contractility, isoprenaline, spontaneous hypertension, ventricular hypertrophy
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© 1980 The Biochemical Society and the Medical Research Society
1980
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