1. Hypertension produced in two-kidney Goldblatt dogs was accompanied by a transient fluid retention, reaching a maximum 4 days after clamping.

2. Prostaglandin E and F concentrations in venous blood from the intact kidney also rose transiently, showing a maximum by the fifth day.

3. The rise in prostaglandin release from the intact kidney may be related to the fluid retention.

Keywords:
extracellular fluid volume, natriuresis, renal hypertension, renal prostaglandin
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© 1978 The Biochemical Society and the Medical Research Society
1978
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