1. The role of renal medullary prostaglandin E has been examined in rats with hypertension induced by sodium chloride and deoxycorticosterone (salt—DOC).

2. Synthesis of prostaglandin E was normal in early salt—DOC hypertension. Indomethcin exacerbated the hypertension, and depressed synthesis of prostaglandin E equally in hypertensive and control rats.

3. Synthesis of prostaglandin E was depressed in rats with late salt—DOC hypertension.

4. The results lend support to the concept that prostaglandin E is involved in the regulation of arterial pressure.

Keywords:
deoxycorticosterone, hypertension, kidney, prostaglandins, sodium chloride
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© 1976 The Biochemical Society and the Medical Research Society
1976
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