The Effect of Frusemide on Water and Electrolyte Absorption from the Human Jejunum

1. Frusemide, in a dose of 120 nmol (40 mg) administered intravenously, significantly reduced the absorption of water and electrolytes from the human jejunum, a double-lumen perfusion system with proximal occluding balloons being used. Net secretion of water and electrolytes occurred in some subjects.

2. No significant change in water and electrolyte absorption was observed with 60 nmol (20 mg) of frusemide.

3. These findings may explain the diarrhoea which may be induced by frusemide in some patients.