1. 1,25-Dihydroxycholecalciferol (1,25-(OH)2-D3) was given at a dose of 5.0 nmol (2.1 μg) daily by mouth for 4–12 days to three patients with hypophosphataemic (type I), vitamin D-resistant rickets.

2. 1,25-(OH)2-D3 increased intestinal absorption and urinary excretion of calcium without significant effect on the renal handling of phosphate or its plasma concentration.

3. It is concluded that in this type of vitamin D-resistant rickets the renal phosphate abnormality is unlikely to be due to diminished endogenous production of 1,25-(OH)2-D3.

4. The difference between this condition and other hypophosphataemic states is discussed.

Keywords:
vitamin D, 1,25-dihydroxycholecalciferol, renal tubular rickets, phosphate metabolism
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© 1975 The Biochemical Society and the Medical Research Society
1975
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