1. Adenosine triphosphatase activity dependent on Mg2+ and activated by Na+ and K+ has been found in a microsomal fraction of homogenates of human postmortem kidneys.

2. Various characteristics of the enzyme system are described.

3. Activity is greater in the medulla than in the cortex.

4. Diuretic drugs inhibit activity in vitro only at high concentrations.

Keywords:
adenosine triphosphatase, kidney, diuretics
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© 1972 The Biochemical Society and the Medical Research Society
1972
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