The Effect of Methylguanidine on Tissue Respiration in Vitro

1. Slices of rat cerebral cortex, kidney and liver were incubated with Robinson's medium and the oxygen uptake measured for 4 h.

2. Methylguanidine was added to the incubation medium after 1 h to give final concentrations up to four times those found in chronic uraemia.

3. No significant inhibition of oxygen uptake was found at any of the concentrations tested.