Airway infections are considered as one of the vital factors driving the pathophysiology of chronic lung disease with significant influences on disease trajectory. Opportunistic lung microbes in diseased conditions induce excessive exacerbations and contribute to airflow limitation. Though there has been considerable amount of information that ascertains their links with airway inflammation, the intricate interaction in clinical conditions are poorly understood and requires further deciphering. Current therapeutic interventions for such pathologies are few and lack the ability to modulate underlying dysfunctional immunity as well as suppress the excessive infectious conditions. Thus, in this Commentary we provide a focused outlook on the mechanisms involved in microbial infestation in lung diseases and provides important information on new therapeutic interventions including the potential role of Resolvins and their derivatives as alternative therapeutic agents in combating such multifaceted pathological mechanisms.
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February 2018
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Cover Image
Cover Image
A representative image of an airway from a mouse sensitized and challenged with an allergen. The histological image was captured 24 hours after allergen exposure at which point airway hyperresponsiveness persists without any discernible change to wall structure. In Clinical Science volume 132, issue 3, Wang et al. report on the effects of airway remodelling and allergy on airway responsiveness; for details see pages 327–338. Image kindly provided by Kimberley C.W. Wang (The University of Western Australia).
Commentary|
February 08 2018
Understanding novel mechanisms of microbial pathogenesis in chronic lung disease: implications for new therapeutic targets
Mathew Suji Eapen;
Mathew Suji Eapen
1Department of Laboratory Medicine, School of Health Sciences, College of Health and Medicine, University of Tasmania, Launceston, Tasmania, Australia
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Sukhwinder Singh Sohal
1Department of Laboratory Medicine, School of Health Sciences, College of Health and Medicine, University of Tasmania, Launceston, Tasmania, Australia
Correspondence: Sukhwinder Singh Sohal (sssohal@utas.edu.au)
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Publisher: Portland Press Ltd
Received:
November 29 2017
Revision Received:
December 31 2017
Accepted:
January 13 2018
Online ISSN: 1470-8736
Print ISSN: 0143-5221
© 2018 The Author(s). Published by Portland Press Limited on behalf of the Biochemical Society
2018
Clin Sci (Lond) (2018) 132 (3): 375–379.
Article history
Received:
November 29 2017
Revision Received:
December 31 2017
Accepted:
January 13 2018
Connected Content
Citation
Mathew Suji Eapen, Sukhwinder Singh Sohal; Understanding novel mechanisms of microbial pathogenesis in chronic lung disease: implications for new therapeutic targets. Clin Sci (Lond) 14 February 2018; 132 (3): 375–379. doi: https://doi.org/10.1042/CS20171261
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