Impaired wound healing and ulceration caused by diabetes mellitus, is a significant healthcare burden, markedly impairs quality of life for patients, and is the major cause of amputation worldwide. Current experimental approaches used to investigate the complex wound healing process often involve cultures of fibroblasts and/or keratinocytes in vitro, which can be limited in terms of complexity and capacity, or utilisation of rodent models in which the mechanisms of wound repair differ substantively from that in humans. However, advances in tissue engineering, and the discovery of strategies to reprogramme adult somatic cells to pluripotency, has led to the possibility of developing models of human skin on a large scale. Generation of induced pluripotent stem cells (iPSCs) from tissues donated by diabetic patients allows the (epi)genetic background of this disease to be studied, and the ability to differentiate iPSCs to multiple cell types found within skin may facilitate the development of more complex skin models; these advances offer key opportunities for improving modelling of wound healing in diabetes, and the development of effective therapeutics for treatment of chronic wounds.
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August 2018
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A depiction of the mechanism of cellular autophagy showing the fusion of a lysosome with an autophagosome. The various molecules involved in the process can be seen alongside different microbes within the autophagosome. In this issue of Clinical Science, Li et al. (issue 15, pages 1645–1667) investigate the role of HMGB1-induced autophagy in liver fibrosis, and Andrade-Silva et al. (issue 16, pages 1725–1739) discuss the involvement of TLR2 and TLR4 in autophagy associated with cisplatin-induced acute kidney injury.
Review Article|
August 14 2018
The potential of human induced pluripotent stem cells for modelling diabetic wound healing in vitro
Patricia E. Martin;
Patricia E. Martin
1GCU Skin Research Tissue Bank, Department of Life Sciences, School of Health and Life Sciences, Glasgow Caledonian University, Glasgow G4 0BA, U.K.
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Erin M. O’Shaughnessy;
Erin M. O’Shaughnessy
1GCU Skin Research Tissue Bank, Department of Life Sciences, School of Health and Life Sciences, Glasgow Caledonian University, Glasgow G4 0BA, U.K.
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Catherine S. Wright;
Catherine S. Wright
1GCU Skin Research Tissue Bank, Department of Life Sciences, School of Health and Life Sciences, Glasgow Caledonian University, Glasgow G4 0BA, U.K.
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Annette Graham
1GCU Skin Research Tissue Bank, Department of Life Sciences, School of Health and Life Sciences, Glasgow Caledonian University, Glasgow G4 0BA, U.K.
Correspondence: Annette Graham (Ann.Graham@gcu.ac.uk)
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Publisher: Portland Press Ltd
Received:
April 10 2018
Revision Received:
June 28 2018
Accepted:
July 23 2018
Online ISSN: 1470-8736
Print ISSN: 0143-5221
© 2018 The Author(s). Published by Portland Press Limited on behalf of the Biochemical Society
2018
Clin Sci (Lond) (2018) 132 (15): 1629–1643.
Article history
Received:
April 10 2018
Revision Received:
June 28 2018
Accepted:
July 23 2018
Citation
Patricia E. Martin, Erin M. O’Shaughnessy, Catherine S. Wright, Annette Graham; The potential of human induced pluripotent stem cells for modelling diabetic wound healing in vitro. Clin Sci (Lond) 16 August 2018; 132 (15): 1629–1643. doi: https://doi.org/10.1042/CS20171483
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