The purpose of this review is to provide an overview of diagnosis, prognosis and management of heart failure (HF) with reduced ejection fraction (HFrEF). Specifically, this review is divided into three sections. The first section will address biomarkers. The discovery of biomarkers has allowed further understanding of the pathophysiology of HF and provides insight into potential therapeutic targets. This review will focus on novel applications of natriuretic peptides (NPs) in clinical trials. Next, emerging biomarkers of HF, such as ST2, galectin-3 and copeptin, will be discussed. The second section aims to highlight HF therapies, including novel drugs and durable devices. The last section will review home haemodynamic monitoring and mobile health. We aim to provide context for the understanding of novel diagnostic and therapeutic advances in HF that are still in phase II or III trials, and have yet to become widely available.
Skip Nav Destination
Article navigation
April 2017
-
Cover Image
Cover Image
An MRI angiogram of the brain vasculature (arteries). Articles in the area of small vessels, dementia and chronic diseases published in Clinical Science throughout 2017 are being gathered together as a collection that can be viewed at http://www.portlandpresspublishing.com/cc/small-vessels.
Review Article|
March 17 2017
Advances in heart failure: a review of biomarkers, emerging pharmacological therapies, durable mechanical support and telemonitoring
Yasbanoo Moayedi;
Yasbanoo Moayedi
1Department of Medicine, Division of Cardiology, University Health Network, Toronto, Canada
Search for other works by this author on:
Heather J. Ross
1Department of Medicine, Division of Cardiology, University Health Network, Toronto, Canada
2Director of Cardiac Transplant Program, Peter Munk Cardiac Centre, Toronto, Canada
Correspondence: Heather J. Ross (heather.ross@uhn.ca)
Search for other works by this author on:
Publisher: Portland Press Ltd
Received:
June 08 2016
Revision Received:
December 14 2016
Accepted:
January 05 2017
Online ISSN: 1470-8736
Print ISSN: 0143-5221
© 2017 The Author(s). published by Portland Press Limited on behalf of the Biochemical Society
2017
Clin Sci (Lond) (2017) 131 (7): 553–566.
Article history
Received:
June 08 2016
Revision Received:
December 14 2016
Accepted:
January 05 2017
Citation
Yasbanoo Moayedi, Heather J. Ross; Advances in heart failure: a review of biomarkers, emerging pharmacological therapies, durable mechanical support and telemonitoring. Clin Sci (Lond) 1 April 2017; 131 (7): 553–566. doi: https://doi.org/10.1042/CS20160196
Download citation file:
Sign in
Don't already have an account? Register
Sign in to your personal account
You could not be signed in. Please check your email address / username and password and try again.
Captcha Validation Error. Please try again.