Gut micro-organisms are recognized as crucial regulators of host immunity and the microbiota has been implicated in several inflammatory, immune, inflammatory or even psychiatric disorders. Therefore the analysis of the complex interactions between gut microbiota and the host is currently under intense investigation. Most of our knowledge stems from the study of animal models while translational research and data in humans are necessary to move the field forward and to evolve to diagnostic and therapeutic application. Amongst the microbial by-products, short chain fatty acids such as acetate yielded by fermentation of non-digestible fibers, were pointed as metabolic modulators. Here we highlight a study evaluating the effects of colonic infusion of one of the short chain fatty acids, acetate, in a cohort of overweight and obese normoglycaemic subjects.
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Commentary| October 11 2016
Colonic acetate in obesity: location matters!
Laure B. Bindels;
†Laboratory of Hepato-Gastroenterology, Institut de Recherche Expérimentale et Clinique, Université catholique de Louvain, Avenue E. Mounier, 53, B1.52.01, 1200 Brussels, Belgium
Correspondence: Professor Isabelle Leclercq (email firstname.lastname@example.org).
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Publisher: Portland Press Ltd
Received: July 21 2016
Revision Received: September 05 2016
Accepted: September 05 2016
Online ISSN: 1470-8736
Print ISSN: 0143-5221
© 2016 The Author(s). published by Portland Press Limited on behalf of the Biochemical Society
Laure B. Bindels, Isabelle Leclercq; Colonic acetate in obesity: location matters!. Clin Sci (Lond) 1 November 2016; 130 (22): 2083–2086. doi: https://doi.org/10.1042/CS20160556
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