Normal skeletal muscle metabolism is essential for whole body metabolic homoeostasis and disruptions in muscle metabolism are associated with a number of chronic diseases. Transcriptional control of metabolic enzyme expression is a major regulatory mechanism for muscle metabolic processes. Substantial evidence is emerging that highlights the importance of epigenetic mechanisms in this process. This review will examine the importance of epigenetics in the regulation of muscle metabolism, with a particular emphasis on DNA methylation and histone acetylation as epigenetic control points. The emerging cross-talk between metabolism and epigenetics in the context of health and disease will also be examined. The concept of inheritance of skeletal muscle metabolic phenotypes will be discussed, in addition to emerging epigenetic therapies that could be used to alter muscle metabolism in chronic disease states.
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July 2016
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Cover Image
Sagittal section through the retina of a hypertensive dTGR rat: staining in blue (DAPI) of cell nuclei and in red GFAP (glial fibrillary acidic protein). The GFAP staining shows activated astrocytes in the ganglion cell layer of the retina. See pp. 1075–1088 for further details. Image kindly provided by Olaf Strauß.
Review Article|
May 23 2016
Epigenetic regulation of skeletal muscle metabolism
Kirsten F. Howlett;
Kirsten F. Howlett
*Institute for Physical Activity and Nutrition, School of Exercise and Nutrition Sciences, Deakin University, Waurn Ponds, Victoria 3217, Australia
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Sean L. McGee
†Metabolic Reprogramming Laboratory, Metabolic Research Unit, School of Medicine and Centre for Molecular and Medical Research, Deakin University, Waurn Ponds, Victoria 3217, Australia
Correspondence: Sean L. McGee (email sean.mcgee@deakin.edu.au).
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Publisher: Portland Press Ltd
Received:
February 16 2016
Revision Received:
February 23 2016
Accepted:
March 15 2016
Online ISSN: 1470-8736
Print ISSN: 0143-5221
© 2016 The Author(s). published by Portland Press Limited on behalf of the Biochemical Society
2016
Clin Sci (Lond) (2016) 130 (13): 1051–1063.
Article history
Received:
February 16 2016
Revision Received:
February 23 2016
Accepted:
March 15 2016
Citation
Kirsten F. Howlett, Sean L. McGee; Epigenetic regulation of skeletal muscle metabolism. Clin Sci (Lond) 1 July 2016; 130 (13): 1051–1063. doi: https://doi.org/10.1042/CS20160115
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