Modulation of the RAS (renin–angiotensin system), in particular of the function of the hormones AngII (angiotensin II) and Ang-(1–7) [angiotensin-(1–7)], is an important target for pharmacotherapy in the cardiovascular system. In the classical view, such modulation affects cardiovascular cells to decrease hypertrophy, fibrosis and endothelial dysfunction, and improves diuresis. In this view, excessive stimulation of AT1 receptors (AngII type 1 receptors) fulfils a detrimental role, as it promotes cardiovascular pathogenesis, and this is opposed by stimulation of the AT2 receptor (angiotensin II type 2 receptor) and the Ang-(1–7) receptor encoded by the Mas proto-oncogene. In recent years, this view has been broadened with the observation that the RAS regulates bone marrow stromal cells and stem cells, thus involving haematopoiesis and tissue regeneration by progenitor cells. This change of paradigm has enlarged the field of perspectives for therapeutic application of existing as well as newly developed medicines that alter angiotensin signalling, which now stretches beyond cardiovascular therapy. In the present article, we review the role of AngII and Ang-(1–7) and their respective receptors in haematopoietic and mesenchymal stem cells, and discuss possible pharmacotherapeutical implications.
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Review Article|
April 24 2012
The renin–angiotensin system, bone marrow and progenitor cells
Matej Durik;
Matej Durik
1Division of Vascular Medicine and Pharmacology, Department of Internal Medicine, Erasmus Medical Center, Dr. Molewaterplein 50, 3015 GE Rotterdam, The Netherlands
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Bruno Sevá Pessôa;
Bruno Sevá Pessôa
1Division of Vascular Medicine and Pharmacology, Department of Internal Medicine, Erasmus Medical Center, Dr. Molewaterplein 50, 3015 GE Rotterdam, The Netherlands
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Anton J. M. Roks
1Division of Vascular Medicine and Pharmacology, Department of Internal Medicine, Erasmus Medical Center, Dr. Molewaterplein 50, 3015 GE Rotterdam, The Netherlands
Correspondence: Dr Anton J. M. Roks (email a.roks@erasmusmc.nl).
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Publisher: Portland Press Ltd
Received:
December 16 2011
Revision Received:
January 30 2012
Accepted:
March 05 2012
Online ISSN: 1470-8736
Print ISSN: 0143-5221
© The Authors Journal compilation © 2012 Biochemical Society
2012
Clin Sci (Lond) (2012) 123 (4): 205–223.
Article history
Received:
December 16 2011
Revision Received:
January 30 2012
Accepted:
March 05 2012
Citation
Matej Durik, Bruno Sevá Pessôa, Anton J. M. Roks; The renin–angiotensin system, bone marrow and progenitor cells. Clin Sci (Lond) 1 August 2012; 123 (4): 205–223. doi: https://doi.org/10.1042/CS20110660
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