Cardiovascular and autonomic dysfunction have been suggested to underlie the symptoms accompanying CFS (chronic fatigue syndrome). In the present issue of Clinical Science, Hurwitz and co-workers have investigated whether deficits were present in cardiac output and blood volume in a cohort of patients with CFS and if these were linked to illness severity and sedentary lifestyle. The results clearly demonstrate reduced cardiac stroke volume and cardiac output in more severely afflicted patients with CFS, which is primarily attributable to a measurable reduction in blood volume. Similar findings are observed in microgravity and bed rest deconditioning, in forms of orthostatic intolerance and, to a lesser extent, in sedentary people. The circulatory consequences of reduced cardiac output may help to account for many of the findings of the syndrome.
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Commentary|
October 19 2009
Chronic fatigue syndrome: comments on deconditioning, blood volume and resulting cardiac function
Julian M. Stewart
1Department of Pediatrics and Physiology, New York Medical College, Hawthorne, NY 10532, U.S.A.
Correspondence: Professor Julian M. Stewart (email stewart@nymc.edu).
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Publisher: Portland Press Ltd
Received:
June 15 2009
Accepted:
June 18 2009
Accepted Manuscript online:
June 18 2009
Online ISSN: 1470-8736
Print ISSN: 0143-5221
© The Authors Journal compilation © 2010 Biochemical Society
2010
Clin Sci (Lond) (2010) 118 (2): 121–123.
Article history
Received:
June 15 2009
Accepted:
June 18 2009
Accepted Manuscript online:
June 18 2009
Citation
Julian M. Stewart; Chronic fatigue syndrome: comments on deconditioning, blood volume and resulting cardiac function. Clin Sci (Lond) 15 January 2010; 118 (2): 121–123. doi: https://doi.org/10.1042/CS20090327
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