Atherosclerosis is the pathological process that underlies the development of cardiovascular disease, a leading cause of mortality. Atherosclerotic plaque formation is driven by the recruitment of inflammatory monocytes into the artery wall, their differentiation into macrophages and the subsequent transformation of macrophages into cholesterol-laden foam cells. Models of hypercholesterolaemia such as the ApoE (apolipoprotein E)−/− mouse and the application of transgenic technologies have allowed us to undertake a thorough dissection of the cellular and molecular biology of the atherosclerotic disease process. Murine models have emphasized the central role of inflammation in atherogenesis and have been instrumental in the identification of adhesion molecules that support monocyte recruitment, scavenger receptors that facilitate cholesterol uptake by macrophages and other macrophage activation receptors. The study of mice deficient in multiple members of the chemokine family, and their receptors, has shown that chemokines play a critical role in promoting atherosclerotic plaque formation. In the present review, we will discuss novel therapeutic avenues for the treatment of cardiovascular disease that derive directly from our current understanding of atherogenesis gained in experimental animal models.
Skip Nav Destination
Article navigation
Review Article|
March 09 2010
Inflammatory cell recruitment in cardiovascular disease: murine models and potential clinical applications
Eileen McNeill;
Eileen McNeill
*Department of Cardiovascular Medicine, University of Oxford, John Radcliffe Hospital, Oxford OX3 9DU, U.K.
Search for other works by this author on:
Keith M. Channon;
Keith M. Channon
*Department of Cardiovascular Medicine, University of Oxford, John Radcliffe Hospital, Oxford OX3 9DU, U.K.
Search for other works by this author on:
David R. Greaves
†Sir William Dunn School of Pathology, University of Oxford, Oxford OX1 3RE, U.K.
Correspondence: Dr David R. Greaves (email David.Greaves@path.ox.ac.uk).
Search for other works by this author on:
Publisher: Portland Press Ltd
Received:
September 23 2009
Revision Received:
January 04 2010
Accepted:
January 22 2010
Online ISSN: 1470-8736
Print ISSN: 0143-5221
© The Authors Journal compilation © 2010 Biochemical Society
2010
Clin Sci (Lond) (2010) 118 (11): 641–655.
Article history
Received:
September 23 2009
Revision Received:
January 04 2010
Accepted:
January 22 2010
Citation
Eileen McNeill, Keith M. Channon, David R. Greaves; Inflammatory cell recruitment in cardiovascular disease: murine models and potential clinical applications. Clin Sci (Lond) 1 June 2010; 118 (11): 641–655. doi: https://doi.org/10.1042/CS20090488
Download citation file:
Sign in
Don't already have an account? Register
Sign in to your personal account
You could not be signed in. Please check your email address / username and password and try again.
Captcha Validation Error. Please try again.