The aim of the present study was to determine the time course of changes in oxidant/antioxidant status, as well as serum glucose, insulin, leptin and lipid levels, liver adipose tissue and muscle lipid and protein contents, in cafeteria-diet-fed dams during gestation and lactation, and in their offspring throughout adulthood. Food intake was also evaluated. The cafeteria diet induced a significant increase in maternal body and relative adipose tissue weights, daily energy intake, and plasma glucose, insulin, leptin and lipid levels at parturition (day 0) and at the end of lactation (day 21). Plasma total antioxidant status [ORAC (oxygen radical absorbance capacity)], erythrocyte catalase and SOD (superoxide dismutase) activities were lower, whereas plasma hydroperoxide and carbonyl protein levels were higher in cafeteria-diet-fed mothers compared with control mothers at days 0 and 21. Pups from cafeteria-diet-fed dams, both males and females, also had consistently higher body and relative adipose tissue weights, and plasma glucose, insulin, leptin, triacylglycerol (triglyceride) and cholesterol levels at birth (day 0), weaning (day 21) and 3 months of age (day 90). These offspring had significantly lower ORAC and catalase activity, and higher plasma hydroperoxide and carbonyl protein levels and SOD activity at birth, at days 21 and 90 compared with control offspring. In conclusion, excessive maternal fat and energy intake can play an important role in the development of metabolic disorders in the offspring. Maternal oxidative stress may be among the responsible factors. Fetal oxidative stress may present an additional confounding influence and probably contributes to additional disorders, aggravating features of the metabolic syndrome. An improvement in maternal oxidant/antioxidant status during pregnancy and lactation, with adequate nutrition, could have beneficial effects on the progeny.
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April 2009
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Research Article|
March 16 2009
Time course of changes in serum oxidant/antioxidant status in overfed obese rats and their offspring
Samira Bouanane;
Samira Bouanane
*Laboratory of Physiology and Biochemistry of Nutrition, Department of Molecular and Cellular Biology, University Abou-Bekr Belkaïd, Tlemcen 13000, Algeria
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Nassira B. Benkalfat;
Nassira B. Benkalfat
*Laboratory of Physiology and Biochemistry of Nutrition, Department of Molecular and Cellular Biology, University Abou-Bekr Belkaïd, Tlemcen 13000, Algeria
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Fatima-Zohra Baba Ahmed;
Fatima-Zohra Baba Ahmed
*Laboratory of Physiology and Biochemistry of Nutrition, Department of Molecular and Cellular Biology, University Abou-Bekr Belkaïd, Tlemcen 13000, Algeria
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Hafida Merzouk;
*Laboratory of Physiology and Biochemistry of Nutrition, Department of Molecular and Cellular Biology, University Abou-Bekr Belkaïd, Tlemcen 13000, Algeria
Correspondence: Professor Hafida Merzouk (email hafidamerzouk_2@hotmail.com).
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Nassima S. Mokhtari;
Nassima S. Mokhtari
*Laboratory of Physiology and Biochemistry of Nutrition, Department of Molecular and Cellular Biology, University Abou-Bekr Belkaïd, Tlemcen 13000, Algeria
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Sid-Ahmed Merzouk;
Sid-Ahmed Merzouk
†Department of Physics, Faculty of Sciences, University Abou-Bekr Belkaïd, Tlemcen 13000, Algeria
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Joseph Gresti;
Joseph Gresti
‡INSERM UMR 866, ‘Lipids Nutrition Cancer’, Université de Bourgogne, Faculté des Sciences, 6 Boulevard Gabriel, 21000 Dijon, France
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Christian Tessier;
Christian Tessier
‡INSERM UMR 866, ‘Lipids Nutrition Cancer’, Université de Bourgogne, Faculté des Sciences, 6 Boulevard Gabriel, 21000 Dijon, France
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Michel Narce
Michel Narce
‡INSERM UMR 866, ‘Lipids Nutrition Cancer’, Université de Bourgogne, Faculté des Sciences, 6 Boulevard Gabriel, 21000 Dijon, France
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Publisher: Portland Press Ltd
Received:
August 19 2008
Revision Received:
October 07 2008
Accepted:
November 05 2008
Accepted Manuscript online:
November 05 2008
Online ISSN: 1470-8736
Print ISSN: 0143-5221
© The Authors Journal compilation © 2009 Biochemical Society
2009
Clin Sci (Lond) (2009) 116 (8): 669–680.
Article history
Received:
August 19 2008
Revision Received:
October 07 2008
Accepted:
November 05 2008
Accepted Manuscript online:
November 05 2008
Citation
Samira Bouanane, Nassira B. Benkalfat, Fatima-Zohra Baba Ahmed, Hafida Merzouk, Nassima S. Mokhtari, Sid-Ahmed Merzouk, Joseph Gresti, Christian Tessier, Michel Narce; Time course of changes in serum oxidant/antioxidant status in overfed obese rats and their offspring. Clin Sci (Lond) 1 April 2009; 116 (8): 669–680. doi: https://doi.org/10.1042/CS20080413
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