Recent reports suggest that IGF (insulin-like growth factor)-I and IGFBP-3 (IGF-binding protein-3) have independent and opposing mechanistic effects on insulin. The aim of the present study was to assess the relationship between the IGF-I/IGFBP-3 ratio and the metabolic syndrome. We examined 3281 subjects (1463 men and 1818 women, aged 20–49 years), otherwise healthy adults, who participated in NHANES III (Third National Health and Nutrition Examination Survey), which has released measurements of IGF-I and IGFBP-3. Insulin resistance was estimated using the computer HOMA2 (homoeostatic model assessment 2) model. The updated ATP-III (Adult Treatment Panel III) definition of the metabolic syndrome was used. We applied adjusted logistic and linear regression models. After adjusting for age and race, men and women in the lowest quartile of the IGF-I/IGFBP-3 ratio were 3-fold more likely to meet the ATP-III definition of the metabolic syndrome and twice as likely to be insulin-resistant. Mean values of the IGF-I/IGFBP-3 ratio decreased significantly as the number of metabolic syndrome components increased (P<0.0001, as determined by ANOVA). The area under the ROC (receiver operating characteristic) curve for detecting insulin resistance using the IGF-I/IGFBP-3 ratio was 0.760, significantly improving upon either protein alone (P=0.01). In conclusion, the IGF-I/IGFBP-3 ratio is significantly associated with the metabolic syndrome. Calculating the ratio of these two proteins may provide insight into the metabolic syndrome clustering phenomenon.
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March 2009
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Research Article|
February 12 2009
IGF-I/IGFBP-3 ratio: a mechanistic insight into the metabolic syndrome
Justo Sierra-Johnson;
*Atherosclerosis Research Unit, Department of Medicine, Karolinska University Hospital, S-171 76 Stockholm, Sweden
Correspondence: Dr Justo Sierra-Johnson (jusier@ki.se).
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Abel Romero-Corral;
Abel Romero-Corral
†Department of Internal Medicine, Division of Cardiovascular Diseases, Mayo Clinic Foundation, Rochester, MN 55905, U.S.A.
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Virend K. Somers;
Virend K. Somers
†Department of Internal Medicine, Division of Cardiovascular Diseases, Mayo Clinic Foundation, Rochester, MN 55905, U.S.A.
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Francisco Lopez-Jimenez;
Francisco Lopez-Jimenez
†Department of Internal Medicine, Division of Cardiovascular Diseases, Mayo Clinic Foundation, Rochester, MN 55905, U.S.A.
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Anders Mälarstig;
Anders Mälarstig
*Atherosclerosis Research Unit, Department of Medicine, Karolinska University Hospital, S-171 76 Stockholm, Sweden
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Kerstin Brismar;
Kerstin Brismar
‡Department of Molecular Medicine and Surgery, Karolinska Institutet, SE-171 77 Stockholm, Sweden
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Anders Hamsten;
Anders Hamsten
*Atherosclerosis Research Unit, Department of Medicine, Karolinska University Hospital, S-171 76 Stockholm, Sweden
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Rachel M. Fisher;
Rachel M. Fisher
*Atherosclerosis Research Unit, Department of Medicine, Karolinska University Hospital, S-171 76 Stockholm, Sweden
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Mai-Lis Hellénius
Mai-Lis Hellénius
*Atherosclerosis Research Unit, Department of Medicine, Karolinska University Hospital, S-171 76 Stockholm, Sweden
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Publisher: Portland Press Ltd
Received:
August 05 2008
Revision Received:
September 17 2008
Accepted:
September 24 2008
Accepted Manuscript online:
September 24 2008
Online ISSN: 1470-8736
Print ISSN: 0143-5221
© The Authors Journal compilation © 2009 Biochemical Society
2009
Clin Sci (Lond) (2009) 116 (6): 507–512.
Article history
Received:
August 05 2008
Revision Received:
September 17 2008
Accepted:
September 24 2008
Accepted Manuscript online:
September 24 2008
Citation
Justo Sierra-Johnson, Abel Romero-Corral, Virend K. Somers, Francisco Lopez-Jimenez, Anders Mälarstig, Kerstin Brismar, Anders Hamsten, Rachel M. Fisher, Mai-Lis Hellénius; IGF-I/IGFBP-3 ratio: a mechanistic insight into the metabolic syndrome. Clin Sci (Lond) 1 March 2009; 116 (6): 507–512. doi: https://doi.org/10.1042/CS20080382
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