The metabolic response when aerobic exercise is performed after the ingestion of glucose plus fructose is unclear. In the present study, we administered two beverages containing GluF (glucose+fructose) or Glu (glucose alone) in a randomized cross-over design to 20 healthy aerobically trained volunteers to compare the hormonal and lipid responses provoked during aerobic exercise and the recovery phase. After ingesting the beverages and a 15-min resting period, volunteers performed 30 min of moderate aerobic exercise. Urinary and blood samples were taken at baseline (t−15), during the exercise (t0, t15 and t30) and during the recovery phase (t45, t75 and t105). Plasma insulin concentrations were higher halfway through the exercise period and during acute recuperation (t15 and t75; P<0.05) following ingestion of GluF than after Glu alone, without any differences between the effects of either intervention on plasma glucose concentrations. Towards the end of the exercise period, urinary catecholamine concentrations were lower following GluF (t45; P<0.05). Plasma triacylglycerol (triglyceride) concentrations were higher after the ingestion of GluF compared with Glu (t15, t30, t45 and t105; P<0.05). Furthermore, with GluF, we observed higher levels of lipoperoxides (t15, t30, t45 and t105; P<0.05) and oxidized LDL (low-density lipoprotein; t30; P<0.05) compared with after the ingestion of Glu alone. In conclusion, hormonal and lipid alterations are provoked during aerobic exercise and recovery by the addition of a dose of fructose to the pre-exercise ingestion of glucose.
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January 2009
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Research Article|
December 15 2008
Fructose modifies the hormonal response and modulates lipid metabolism during aerobic exercise after glucose supplementation
Juan M. Fernández;
*Lipids and Atherosclerosis Research Unit, Reina Sofia University Hospital, CIBER Fisiopatología de la Obesidad y Nutricion (CIBEROBN), 14004 Córdoba, Spain
Correspondence: Dr Juan M. Fernández (email juf_nutryinves@yahoo.com).
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Marzo E. da Silva-Grigoletto;
Marzo E. da Silva-Grigoletto
*Lipids and Atherosclerosis Research Unit, Reina Sofia University Hospital, CIBER Fisiopatología de la Obesidad y Nutricion (CIBEROBN), 14004 Córdoba, Spain
†Andalusian Centre of Sports Medicine, 14003 Córdoba, Spain
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Juan A. Ruano-Ruíz;
Juan A. Ruano-Ruíz
*Lipids and Atherosclerosis Research Unit, Reina Sofia University Hospital, CIBER Fisiopatología de la Obesidad y Nutricion (CIBEROBN), 14004 Córdoba, Spain
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Javier Caballero-Villarraso;
Javier Caballero-Villarraso
*Lipids and Atherosclerosis Research Unit, Reina Sofia University Hospital, CIBER Fisiopatología de la Obesidad y Nutricion (CIBEROBN), 14004 Córdoba, Spain
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Rafael Moreno-Luna;
Rafael Moreno-Luna
*Lipids and Atherosclerosis Research Unit, Reina Sofia University Hospital, CIBER Fisiopatología de la Obesidad y Nutricion (CIBEROBN), 14004 Córdoba, Spain
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Isaac Túnez-Fiñana;
Isaac Túnez-Fiñana
‡Department of Biochemistry and Molecular Biology, School of Medicine, University of Córdoba, 14071 Córdoba, Spain
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Inmaculada Tasset-Cuevas;
Inmaculada Tasset-Cuevas
‡Department of Biochemistry and Molecular Biology, School of Medicine, University of Córdoba, 14071 Córdoba, Spain
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Pablo Pérez-Martínez;
Pablo Pérez-Martínez
*Lipids and Atherosclerosis Research Unit, Reina Sofia University Hospital, CIBER Fisiopatología de la Obesidad y Nutricion (CIBEROBN), 14004 Córdoba, Spain
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José López-Miranda;
José López-Miranda
*Lipids and Atherosclerosis Research Unit, Reina Sofia University Hospital, CIBER Fisiopatología de la Obesidad y Nutricion (CIBEROBN), 14004 Córdoba, Spain
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Francisco Pérez-Jiménez
Francisco Pérez-Jiménez
*Lipids and Atherosclerosis Research Unit, Reina Sofia University Hospital, CIBER Fisiopatología de la Obesidad y Nutricion (CIBEROBN), 14004 Córdoba, Spain
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Publisher: Portland Press Ltd
Received:
April 10 2008
Revision Received:
May 28 2008
Accepted:
June 05 2008
Accepted Manuscript online:
June 05 2008
Online ISSN: 1470-8736
Print ISSN: 0143-5221
© The Authors Journal compilation © 2009 Biochemical Society
2009
Clin Sci (Lond) (2009) 116 (2): 137–145.
Article history
Received:
April 10 2008
Revision Received:
May 28 2008
Accepted:
June 05 2008
Accepted Manuscript online:
June 05 2008
Citation
Juan M. Fernández, Marzo E. da Silva-Grigoletto, Juan A. Ruano-Ruíz, Javier Caballero-Villarraso, Rafael Moreno-Luna, Isaac Túnez-Fiñana, Inmaculada Tasset-Cuevas, Pablo Pérez-Martínez, José López-Miranda, Francisco Pérez-Jiménez; Fructose modifies the hormonal response and modulates lipid metabolism during aerobic exercise after glucose supplementation. Clin Sci (Lond) 1 January 2009; 116 (2): 137–145. doi: https://doi.org/10.1042/CS20080120
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