The aim of the present study was to investigate the acute effect of CABG (coronary artery bypass graft) surgery on the rates of synthesis of muscle protein, the positive acute-phase protein fibrinogen and the negative acute-phase protein albumin. Synthesis rates of muscle protein, fibrinogen and albumin were measured simultaneously before and 4 h after the end of surgery from the incorporation of L-[2H5]phenylalanine (given at 43 mg/kg of body weight) in 12 patients undergoing CABG surgery. Surgery was performed either with the use of extracorporeal circulation with cardiopulmonary bypass (on-pump; n=5) or with the beating heart procedure without cardiopulmonary bypass (off-pump; n=7). Post-surgical muscle protein fractional synthesis rates were decreased by 36±6.5% compared with pre-surgical values (1.59±0.10 compared with 0.97±0.08%/day respectively; P<0.001). In contrast, the synthesis rates of both fibrinogen (36±4 compared with 100±11 mg·day−1·kg−1 of body weight; P<0.0001) and albumin (123±12 compared with 178±19 mg·day−1·kg−1 of body weight; P<0.001) were both significantly increased after surgery. No significant differences were found between surgery performed with or without cardiopulmonary bypass. In conclusion, the results demonstrate that CABG surgery has a profound effect on protein metabolism, with a differential response of protein synthesis in muscle and liver.
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February 2008
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Research Article|
January 15 2008
Altered protein metabolism following coronary artery bypass graft (CABG) surgery
Giuseppe Caso;
*Department of Surgery, Stony Brook University Medical Center, Stony Brook, NY 11794-8191, U.S.A.
Correspondence: Dr Giuseppe Caso (email Giuseppe.Caso@stonybrook.edu).
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James A. Vosswinkel;
James A. Vosswinkel
*Department of Surgery, Stony Brook University Medical Center, Stony Brook, NY 11794-8191, U.S.A.
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Peter J. Garlick;
Peter J. Garlick
†Department of Animal Sciences, University of Illinois, Urbana, IL 61801, U.S.A.
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Mohamed K. Barry;
Mohamed K. Barry
*Department of Surgery, Stony Brook University Medical Center, Stony Brook, NY 11794-8191, U.S.A.
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Thomas V. Bilfinger;
Thomas V. Bilfinger
*Department of Surgery, Stony Brook University Medical Center, Stony Brook, NY 11794-8191, U.S.A.
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Margaret A. Mcnurlan
Margaret A. Mcnurlan
*Department of Surgery, Stony Brook University Medical Center, Stony Brook, NY 11794-8191, U.S.A.
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Publisher: Portland Press Ltd
Received:
August 02 2007
Revision Received:
September 26 2007
Accepted:
October 22 2007
Accepted Manuscript online:
October 22 2007
Online ISSN: 1470-8736
Print ISSN: 0143-5221
© The Authors Journal compilation © 2008 Biochemical Society
2008
Clin Sci (Lond) (2008) 114 (4): 339–346.
Article history
Received:
August 02 2007
Revision Received:
September 26 2007
Accepted:
October 22 2007
Accepted Manuscript online:
October 22 2007
Citation
Giuseppe Caso, James A. Vosswinkel, Peter J. Garlick, Mohamed K. Barry, Thomas V. Bilfinger, Margaret A. Mcnurlan; Altered protein metabolism following coronary artery bypass graft (CABG) surgery. Clin Sci (Lond) 1 February 2008; 114 (4): 339–346. doi: https://doi.org/10.1042/CS20070278
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