In the current dietary recommendations for the treatment and prevention of Type 2 diabetes and its related complications, there is flexibility in the proportion of energy derived from monounsaturated fat and carbohydrate as a replacement for saturated fat. Over the last few years, several population studies have shown that subjects eating a lot of refined grains and processed foods have a much larger increase in waist circumference than those following a diet higher in monounsaturated fat, protein and carbohydrates rich in fibre and whole grain. In the present issue of Clinical Science, Sinitskaya and co-workers have demonstrated that, in normal-weight rodents categorized into groups of high-fat and medium-carbohydrate [53%/30% of energy as fat/carbohydrate; 19.66 kJ/g (4.7 kcal/g)], high-fat and low-carbohydrate [67%/9% of energy as fat/carbohydrate; 21.76 kJ/g (5.2 kcal/g)] and high-fat and carbohydrate-free [75%/0% of energy as fat/carbohydrate; 24.69 kJ/g (5.9 kcal/g)] diets, the high-fat diets containing carbohydrates were both obesogenic and diabetogenic, whereas the very-high-fat and carbohydrate-free diet was not obesogenic but led to insulin resistance and higher risk of cardiovascular disease. This finding may indicate that high-fat diets could easily give rise to an unhealthy diet when combined with carbohydrates, highlighting the significance of macronutrient composition, rather than caloric content, in high-fat diets.
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November 2007
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Commentary|
October 12 2007
High-fat diets: healthy or unhealthy?
Marie C. Guldstrand;
1Obesity Unit, Department of Internal Medicine, Karolinska Institutet, Danderyd Hospital, SE-182 88 Stockholm, Sweden
Correspondence: Dr Marie C. Guldstrand (email marie.guldstrand@ds.se).
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Caroline L. Simberg
Caroline L. Simberg
1Obesity Unit, Department of Internal Medicine, Karolinska Institutet, Danderyd Hospital, SE-182 88 Stockholm, Sweden
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Publisher: Portland Press Ltd
Received:
July 30 2007
Revision Received:
August 22 2007
Accepted:
August 23 2007
Accepted Manuscript online:
August 23 2007
Online ISSN: 1470-8736
Print ISSN: 0143-5221
© The Authors Journal compilation © 2007 Biochemical Society
2007
Clin Sci (Lond) (2007) 113 (10): 397–399.
Article history
Received:
July 30 2007
Revision Received:
August 22 2007
Accepted:
August 23 2007
Accepted Manuscript online:
August 23 2007
Connected Content
A commentary has been published:
Increasing the fat-to-carbohydrate ratio in a high-fat diet prevents the development of obesity but not a prediabetic state in rats
Citation
Marie C. Guldstrand, Caroline L. Simberg; High-fat diets: healthy or unhealthy?. Clin Sci (Lond) 1 November 2007; 113 (10): 397–399. doi: https://doi.org/10.1042/CS20070263
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