Dopamine plays an important role in the pathogenesis of hypertension by regulating epithelial sodium transport, vascular smooth muscle contractility and production of reactive oxygen species and by interacting with the renin–angiotensin and sympathetic nervous systems. Dopamine receptors are classified into D1-like (D1 and D5) and D2-like (D2, D3 and D4) subtypes based on their structure and pharmacology. Each of the dopamine receptor subtypes participates in the regulation of blood pressure by mechanisms specific for the subtype. Some receptors regulate blood pressure by influencing the central and/or peripheral nervous system; others influence epithelial transport and regulate the secretion and receptors of several humoral agents. This review summarizes the physiology of the different dopamine receptors in the regulation of blood pressure, and the relationship between dopamine receptor subtypes and hypertension.
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June 2007
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Review Article|
May 14 2007
The dopaminergic system in hypertension
Chunyu Zeng;
Chunyu Zeng
1
*Department of Cardiology, Daping Hospital, The Third Military Medical University, Chongqing City 400042, People's Republic of China
Correspondence: Dr Chunyu Zeng (email cyzeng1@hotmail.com).
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Meng Zhang;
Meng Zhang
1
*Department of Cardiology, Daping Hospital, The Third Military Medical University, Chongqing City 400042, People's Republic of China
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Laureano D. Asico;
Laureano D. Asico
†Department of Pediatrics, Georgetown University Medical Center, Washington D.C. 20007, U.S.A.
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Gilbert M. Eisner;
Gilbert M. Eisner
‡Department of Medicine, Georgetown University Medical Center, Washington D.C. 20007, U.S.A.
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Pedro A. Jose
Pedro A. Jose
†Department of Pediatrics, Georgetown University Medical Center, Washington D.C. 20007, U.S.A.
§Department of Physiology and Biophysics, Georgetown University Medical Center, Washington D.C. 20007, U.S.A.
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Publisher: Portland Press Ltd
Received:
January 09 2007
Revision Received:
February 07 2007
Accepted:
February 12 2007
Online ISSN: 1470-8736
Print ISSN: 0143-5221
© The Authors Journal compilation © 2007 Biochemical Society
2007
Clin Sci (Lond) (2007) 112 (12): 583–597.
Article history
Received:
January 09 2007
Revision Received:
February 07 2007
Accepted:
February 12 2007
Citation
Chunyu Zeng, Meng Zhang, Laureano D. Asico, Gilbert M. Eisner, Pedro A. Jose; The dopaminergic system in hypertension. Clin Sci (Lond) 1 June 2007; 112 (12): 583–597. doi: https://doi.org/10.1042/CS20070018
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