PPAR (peroxisome-proliferator-activated receptor) is a nuclear receptor. Activation of PPARγ by its ligands could modulate gene transcription, thereby leading to multiple anti-atherogenic and fibrinolytic effects. However, the association between the 161T allele in exon 6 of the PPARγ gene and premature AMI (acute myocardial infarction) is not clear. We recruited 146 patients with premature AMI (onset age ≤50 years) and 146 controls. The C161T polymorphism was examined using PCR and restriction-fragment-length polymorphism. Plasma levels of Ab-ox-LDL (antibody against oxidized low-density lipoprotein) were measured in 27 male smokers, whose genotypes have been identified. The frequency of the PPARγ TT genotype among patients with AMI was significantly higher than that in controls [13% compared with 5.5%; OR (95% CI) 2.7, (1.1–6.5), where OR and CI are odds ratio and confidence interval respectively]. This association was not observed in CC or CT genotypes. Using multivariate logistic regression analyses, we found that the homozygous TT genotype [OR (95% CI), 3.1 (1.2–7.9)], smoking [OR (95% CI), 3.5, (2.1–6.0)], hypertension [OR (95% CI), 3.6, (1.9–6.9)] and diabetes mellitus [OR (95% CI), 3.5 (1.5–8.4)] were independent risk factors for premature AMI. Plasma levels of Ab-ox-LDL were significantly higher in healthy volunteers with the TT genotype compared with those with the CC genotype (49.3±18.1 compared with 24.2±15.2 units/l respectively; P=0.02). Therefore in our study we observed an association between the PPARγ 161 TT genotype and premature AMI. Lipid peroxidation was significantly influenced by the 161T allele.
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November 2004
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Research Article|
October 26 2004
The 161TT genotype in the exon 6 of the peroxisome-proliferator-activated receptor γ gene is associated with premature acute myocardial infarction and increased lipid peroxidation in habitual heavy smokers
Ting-Hsing CHAO;
Ting-Hsing CHAO
*Department of Internal Medicine, College of Medicine, National Cheng Kung University, Tainan, Taiwan
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Yi-Heng LI;
Yi-Heng LI
*Department of Internal Medicine, College of Medicine, National Cheng Kung University, Tainan, Taiwan
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Jyh-Hong CHEN;
*Department of Internal Medicine, College of Medicine, National Cheng Kung University, Tainan, Taiwan
Correspondence: Dr Jyh-Hong Chen (email jyhhong@mail.ncku.edu.tw).
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Hua-Lin WU;
Hua-Lin WU
†Department of Biochemistry, College of Medicine, National Cheng Kung University, Tainan, Taiwan
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Guey-Yueh SHI;
Guey-Yueh SHI
†Department of Biochemistry, College of Medicine, National Cheng Kung University, Tainan, Taiwan
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Ping-Yen LIU;
Ping-Yen LIU
*Department of Internal Medicine, College of Medicine, National Cheng Kung University, Tainan, Taiwan
‡Institute of Clinical Medicine, College of Medicine, National Cheng Kung University, Tainan, Taiwan
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Wei-Chuan TSAI;
Wei-Chuan TSAI
*Department of Internal Medicine, College of Medicine, National Cheng Kung University, Tainan, Taiwan
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How-Ran GUO
How-Ran GUO
§Department of Environmental and Occupational Health, College of Medicine, National Cheng Kung University, Tainan, Taiwan
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Publisher: Portland Press Ltd
Received:
January 14 2004
Revision Received:
May 27 2004
Accepted:
June 24 2004
Accepted Manuscript online:
June 24 2004
Online ISSN: 1470-8736
Print ISSN: 0143-5221
The Biochemical Society
2004
Clin Sci (Lond) (2004) 107 (5): 461–466.
Article history
Received:
January 14 2004
Revision Received:
May 27 2004
Accepted:
June 24 2004
Accepted Manuscript online:
June 24 2004
Citation
Ting-Hsing CHAO, Yi-Heng LI, Jyh-Hong CHEN, Hua-Lin WU, Guey-Yueh SHI, Ping-Yen LIU, Wei-Chuan TSAI, How-Ran GUO; The 161TT genotype in the exon 6 of the peroxisome-proliferator-activated receptor γ gene is associated with premature acute myocardial infarction and increased lipid peroxidation in habitual heavy smokers. Clin Sci (Lond) 1 November 2004; 107 (5): 461–466. doi: https://doi.org/10.1042/CS20040014
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