Endothelin (ET) A receptor antagonists have been shown to be beneficial in rat models of chronic kidney allograft dysfunction. We investigated urinary and plasma ET-1 (uET-1, pET-1) and BigET-1 (uBigET-1, pBigET-1) concentrations, and plasma soluble ET-converting enzyme (ECE) concentration in 310 adult Caucasian kidney allograft recipients with graft survival of more than 2 years from the outpatients department of our clinic. All patients were on cyclosporine A- or FK506-based immunosuppression protocols. From all available measurements since transplantation, we calculated the slope of serum creatinine-1/year (slopeCrea) as a parameter for progression of chronic graft dysfunction, as well as the mean of serum creatinine (meanCrea) from most recent year before measurements as a parameter for actual graft function. The slope of urinary protein excretion/year (slopeProt) and mean of urinary protein concentration (meanProt) from most recent year was calculated analogue. uET-1 and uBigET-1 were adjusted for protein excretion by calculating uET-1/meanProt and uBigET-1/meanProt. Blood and urine probes for measurements were always drawn immediately before morning dosage of immunosuppressants. There was no significant correlation of any measured component of the ET system with slopeCrea or slopeProt. MeanCrea (mg/dl) was significantly correlated with pBigET-1 (fmol/ml) and pET-1 (fmol/ml) (pBigET-1: r = 0.179, P = 0.001; pET-1: r = 0.161, P = 0.009). The other measured components of the ET systems were not significant correlated with meanCrea. In conclusion, the actual graft function is associated with elevated pET-1 and BigET-1 concentrations as it is well known from other forms of impaired kidney function. However, the actual concentration of ET-1, soluble ECE, and BigET-1 in urine and plasma in our study is not associated with parameters for progression of chronic graft dysfunction.
Skip Nav Destination
Article navigation
September 2002
-
Cover Image
Cover Image
Conference Article|
September 01 2002
Activity of the endothelin system in kidney allograft recipients is not associated with progression of chronic graft dysfunction
Torsten SLOWINSKI;
Torsten SLOWINSKI
*Department of Nephrology, University Hospital Charité, Humboldt University of Berlin, D-10098 Berlin, Germany
†Institute of Molecular Biology and Biochemistry, Free University of Berlin, D-14195 Berlin, Germany
Search for other works by this author on:
Thomas SUBKOWSKI;
Thomas SUBKOWSKI
‡Department of Pharmaceutical Research, Knoll AG, D-67008 Ludwigshafen, Germany
Search for other works by this author on:
Petra DIEHR;
Petra DIEHR
*Department of Nephrology, University Hospital Charité, Humboldt University of Berlin, D-10098 Berlin, Germany
Search for other works by this author on:
Daniela BACHERT;
Daniela BACHERT
*Department of Nephrology, University Hospital Charité, Humboldt University of Berlin, D-10098 Berlin, Germany
Search for other works by this author on:
Lutz FRITSCHE;
Lutz FRITSCHE
*Department of Nephrology, University Hospital Charité, Humboldt University of Berlin, D-10098 Berlin, Germany
Search for other works by this author on:
Hans.-H. NEUMAYER;
Hans.-H. NEUMAYER
*Department of Nephrology, University Hospital Charité, Humboldt University of Berlin, D-10098 Berlin, Germany
Search for other works by this author on:
Berthold HOCHER
*Department of Nephrology, University Hospital Charité, Humboldt University of Berlin, D-10098 Berlin, Germany
†Institute of Molecular Biology and Biochemistry, Free University of Berlin, D-14195 Berlin, Germany
Dr B. Hocher, Department of Nephrology, University Hospital Charité, Humboldt University of Berlin, Schumannstrasse 20-21, 10098 Berlin, Germany (e-mail berthold.hocher@charite.de).
Search for other works by this author on:
Publisher: Portland Press Ltd
Online ISSN: 1470-8736
Print ISSN: 0143-5221
© 2002 The Biochemical Society and the Medical Research Society
2002
Clin Sci (Lond) (2002) 103 (s2002): 393S–395S.
Citation
Torsten SLOWINSKI, Thomas SUBKOWSKI, Petra DIEHR, Daniela BACHERT, Lutz FRITSCHE, Hans.-H. NEUMAYER, Berthold HOCHER; Activity of the endothelin system in kidney allograft recipients is not associated with progression of chronic graft dysfunction. Clin Sci (Lond) 1 September 2002; 103 (s2002): 393S–395S. doi: https://doi.org/10.1042/CS103S393S
Download citation file:
Sign in
Don't already have an account? Register
Sign in to your personal account
You could not be signed in. Please check your email address / username and password and try again.
Captcha Validation Error. Please try again.