In order to investigate the immediate (i.e. within 3h) response of albumin synthesis to the administration of endotoxin, as a model of a moderate and well controlled catabolic insult, two measurements employing L-[2H5]phenylalanine were performed in 16 volunteers. One group (n = 8) received an intravenous injection of endotoxin (4ng/kg; lot EC-6) immediately after the first measurement of albumin synthesis, whereas the other group received saline. A second measurement was initiated 1h later. In the endotoxin group, the fractional synthesis rate of albumin was 6.9±0.6%/day (mean±S.D.) in the first measurement. In the second measurement, a significant increase was observed (9.6±1.2%/day; P<0.001). The corresponding values in the control group were were 6.6±0.6%/day and 7.0±0.6%/day respectively (not significant compared with first measurement and P<0.001 compared with the second measurement in the endotoxin group). The absolute synthesis rates of albumin were 148±35 and 201±49mg·kg-1·day-1 before and after endotoxin (P<0.01). In the control group, the corresponding values were 131±21 and 132±20mg·kg-1·day-1 (not significant compared with the first measurement and P<0.01 compared with the second measurement in the endotoxin group). In conclusion, these results indicate that albumin synthesis increases in the very early phase after a catabolic insult, as represented by the administration of endotoxin.
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Research Article|
October 23 2002
Albumin synthesis in humans increases immediately following the administration of endotoxin
Hans BARLE;
*Department of Anaesthesiology and Intensive Care, Huddinge University Hospital, S-141 86 Stockholm, Sweden
Correspondence: Dr Hans Barle (e-mail hans.barle@anaesth.hs.sll.se).
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Anna JANUSZKIEWICZ;
Anna JANUSZKIEWICZ
*Department of Anaesthesiology and Intensive Care, Huddinge University Hospital, S-141 86 Stockholm, Sweden
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Lars HÅLLSTRÖM;
Lars HÅLLSTRÖM
*Department of Anaesthesiology and Intensive Care, Huddinge University Hospital, S-141 86 Stockholm, Sweden
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Pia ESSÉN;
Pia ESSÉN
†Department of Anaesthesiology and Intensive Care, Danderyd Hospital, S-182 88 Stockholm, Sweden, and
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Margaret A. MCNURLAN;
Margaret A. MCNURLAN
‡Department of Surgery, Stony Brook University, Stony Brook, NY 11794, U.S.A.
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Peter J. GARLICK;
Peter J. GARLICK
‡Department of Surgery, Stony Brook University, Stony Brook, NY 11794, U.S.A.
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Jan WERNERMAN
Jan WERNERMAN
*Department of Anaesthesiology and Intensive Care, Huddinge University Hospital, S-141 86 Stockholm, Sweden
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Publisher: Portland Press Ltd
Received:
July 09 2002
Accepted:
July 24 2002
Online ISSN: 1470-8736
Print ISSN: 0143-5221
The Biochemical Society and the Medical Research Society ©2002
2002
Clin Sci (Lond) (2002) 103 (5): 525–531.
Article history
Received:
July 09 2002
Accepted:
July 24 2002
Citation
Hans BARLE, Anna JANUSZKIEWICZ, Lars HÅLLSTRÖM, Pia ESSÉN, Margaret A. MCNURLAN, Peter J. GARLICK, Jan WERNERMAN; Albumin synthesis in humans increases immediately following the administration of endotoxin. Clin Sci (Lond) 1 November 2002; 103 (5): 525–531. doi: https://doi.org/10.1042/cs1030525
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