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Keywords: zebrafish
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Biosci Rep (2022) 42 (6): BSR20220119.
Published: 17 June 2022
... and dimeric subfamilies of apoptotic caspases, called initiator and effector caspases, respectively. We compared the folding and assembly of procaspase-3b from zebrafish to that of human effector procaspases in order to examine the conservation of the folding landscape. Urea-induced equilibrium folding...
Includes: Supplementary data
Biosci Rep (2021) 41 (10): BSR-2018-2320_COR.
Published: 28 October 2021
... © 2021 The Author(s). 2021 This is an open access article published by Portland Press Limited on behalf of the Biochemical Society and distributed under the Creative Commons Attribution License 4.0 (CC BY) . endoglin endothelial cells vasculogenesis zebrafish The authors...
Biosci Rep (2021) 41 (1): BSR20203495.
Published: 29 January 2021
.... Although all caspases prefer aspartate at the P1 position of the substrate, the caspase-6 subfamily shows preference for valine at the P4 position, while caspase-3 shows preference for aspartate. In comparison with human caspases, caspase-3a from zebrafish has relaxed specificity and demonstrates equal...
Includes: Supplementary data
Biosci Rep (2021) 41 (1): BSR20203204.
Published: 06 January 2021
..., extracellular matrix organization, and cell–cell communication. Since only FRZB was evolutionally conserved in the vertebrates, function of FRZB was validated using zebrafish embryos. Knockdown of frzb remarkably reduced vascular integrity in zebrafish embryos. We believe that FRZB is a key gene involved in AAA...
Includes: Supplementary data
Biosci Rep (2020) 40 (1): BSR20194191.
Published: 31 January 2020
...Nwamaka J. Idigo; Dinesh C. Soares; Catherine M. Abbott Zebrafish are valuable model organisms for the study of human single-gene disorders: they are genetically manipulable, their development is well understood, and mutant lines with measurable, disease-appropriate phenotypic abnormalities can...
Includes: Supplementary data
Biosci Rep (2019) 39 (5): BSR20182320.
Published: 21 May 2019
... mechanisms. The majority of HHT1 patients carry endoglin ( ENG ) mutations. Here, we used Danio rerio (zebrafish) as an in vivo model to investigate the effects of endoglin knockdown on vascular development. According to phylogenetic analyses and amino acid sequence similarity analyses, we confirmed...
Includes: Supplementary data
Biosci Rep (2013) 33 (2): e00034.
Published: 04 April 2013
... proteolysis plays a pivotal role in tissue and organ homoeostasis. Altered expression and compartmentalization of CD have been observed in diseased muscle fibres. Whether CD is actively involved in muscle development, homoeostasis and dystrophy remains to be demonstrated. Zebrafish ( Danio rerio ) is emerging...
Biosci Rep (2005) 25 (5-6): 289–297.
Published: 12 October 2005
...Jeroen den Hertog High throughput chemical genetic screens for compounds with specific biological activity in a whole organism are feasible using zebrafish embryos. At least two medium to large scale drug screens have been carried out to date, leading to the identification of compounds that disturb...